• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

IFN-γ surmounts PD-L1/PD1 inhibition to CAR-T cell therapy by upregulating ICAM-1 on tumor cells.

作者信息

Dong E, Yue Xiao-Zhu, Shui Lin, Liu Bin-Rui, Li Qi-Qi, Yang Yun, Luo Hui, Wang Wei, Yang Han-Shuo

机构信息

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, 610041, Chengdu, China.

出版信息

Signal Transduct Target Ther. 2021 Jan 7;6(1):20. doi: 10.1038/s41392-020-00357-7.

DOI:10.1038/s41392-020-00357-7
PMID:33454722
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7811529/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa78/7811529/3fd46652ecfd/41392_2020_357_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa78/7811529/3fd46652ecfd/41392_2020_357_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa78/7811529/3fd46652ecfd/41392_2020_357_Fig1_HTML.jpg

相似文献

1
IFN-γ surmounts PD-L1/PD1 inhibition to CAR-T cell therapy by upregulating ICAM-1 on tumor cells.γ干扰素通过上调肿瘤细胞上的细胞间黏附分子-1（ICAM-1）克服PD-L1/PD1对嵌合抗原受体T细胞（CAR-T）疗法的抑制作用。
Signal Transduct Target Ther. 2021 Jan 7;6(1):20. doi: 10.1038/s41392-020-00357-7.
2
PD-L1 targeting high-affinity NK (t-haNK) cells induce direct antitumor effects and target suppressive MDSC populations.PD-L1 靶向高亲和力 NK（t-haNK）细胞可诱导直接抗肿瘤作用，并靶向抑制性 MDSC 群体。
J Immunother Cancer. 2020 May;8(1). doi: 10.1136/jitc-2019-000450.
3
PD1 Blockade Enhances ICAM1-Directed CAR T Therapeutic Efficacy in Advanced Thyroid Cancer.PD1 阻断增强了针对晚期甲状腺癌的 ICAM1 导向的 CAR T 治疗疗效。
Clin Cancer Res. 2020 Nov 15;26(22):6003-6016. doi: 10.1158/1078-0432.CCR-20-1523. Epub 2020 Sep 4.
4
Programmed cell death protein 1 activation preferentially inhibits CD28.CAR-T cells.程序性细胞死亡蛋白 1 激活优先抑制 CD28.CAR-T 细胞。
Cytotherapy. 2018 Oct;20(10):1259-1266. doi: 10.1016/j.jcyt.2018.07.005. Epub 2018 Oct 9.
5
Preface: More than two decades of modern tumor immunology.前言：二十多年的现代肿瘤免疫学
Methods Enzymol. 2019;629:xxi-xl. doi: 10.1016/S0076-6879(19)30459-8.
6
CAR affinity modulates the sensitivity of CAR-T cells to PD-1/PD-L1-mediated inhibition.嵌合抗原受体（CAR）亲和力调节 CAR-T 细胞对 PD-1/PD-L1 介导的抑制作用的敏感性。
Nat Commun. 2024 Apr 26;15(1):3552. doi: 10.1038/s41467-024-47799-z.
7
PD-1 silencing improves anti-tumor activities of human mesothelin-targeted CAR T cells.PD-1 沉默增强了人间皮素靶向 CAR T 细胞的抗肿瘤活性。
Hum Immunol. 2021 Feb;82(2):130-138. doi: 10.1016/j.humimm.2020.12.002. Epub 2020 Dec 16.
8
Therapeutic effect of dual CAR-T targeting PDL1 and MUC16 antigens on ovarian cancer cells in mice.双 CAR-T 靶向 PDL1 和 MUC16 抗原对小鼠卵巢癌细胞的治疗效果。
BMC Cancer. 2020 Jul 20;20(1):678. doi: 10.1186/s12885-020-07180-x.
9
Silencing PD-1 and PD-L1: the potential of PolyPurine Reverse Hoogsteen hairpins for the elimination of tumor cells.沉默程序性死亡蛋白1（PD-1）和程序性死亡配体1（PD-L1）：聚嘌呤反向Hoogsteen发夹结构在消除肿瘤细胞方面的潜力
Immunotherapy. 2019 Apr;11(5):369-372. doi: 10.2217/imt-2018-0215.
10
PD1CD28 chimeric molecule enhances EGFRvⅢ specific CAR-T cells in xenograft experiments in mouse models.PD1CD28 嵌合分子增强了异种移植实验中 EGFRvⅢ 特异性 CAR-T 细胞在小鼠模型中的作用。
PLoS One. 2024 Oct 1;19(10):e0310430. doi: 10.1371/journal.pone.0310430. eCollection 2024.

引用本文的文献

1
STING activation improves T-cell-engaging immunotherapy for acute myeloid leukemia.STING激活可改善急性髓系白血病的T细胞接合免疫疗法。
Blood. 2025 May 8;145(19):2149-2160. doi: 10.1182/blood.2024026934.
2
Tumor cells escape immunosurveillance by hampering LFA-1.肿瘤细胞通过阻碍淋巴细胞功能相关抗原-1（LFA-1）来逃避免疫监视。
Front Immunol. 2025 Jan 22;16:1519841. doi: 10.3389/fimmu.2025.1519841. eCollection 2025.
3
Bidirectional regulation of the cGAS-STING pathway in the immunosuppressive tumor microenvironment and its association with immunotherapy.

本文引用的文献

1
Engineering CAR-T Cells for Improved Function Against Solid Tumors.工程化 CAR-T 细胞以改善对实体瘤的功能。
Front Immunol. 2018 Oct 29;9:2493. doi: 10.3389/fimmu.2018.02493. eCollection 2018.
2
Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression.调节PD-L1和PD-L2表达的干扰素受体信号通路
Cell Rep. 2017 May 9;19(6):1189-1201. doi: 10.1016/j.celrep.2017.04.031.
3
Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma.与黑色素瘤中PD-1阻断获得性耐药相关的突变
双向调控 cGAS-STING 通路在免疫抑制性肿瘤微环境中的作用及其与免疫治疗的关系。
Front Immunol. 2024 Oct 11;15:1470468. doi: 10.3389/fimmu.2024.1470468. eCollection 2024.
4
Development of a Competitive Nutrient-Based T-Cell Immunotherapy Designed to Block the Adaptive Warburg Effect in Acute Myeloid Leukemia.一种旨在阻断急性髓系白血病中适应性瓦伯格效应的基于竞争性营养物质的T细胞免疫疗法的开发。
Biomedicines. 2024 Oct 3;12(10):2250. doi: 10.3390/biomedicines12102250.
5
Challenges and future perspectives for high-throughput chimeric antigen receptor T cell discovery.高通量嵌合抗原受体 T 细胞发现的挑战和未来展望。
Curr Opin Biotechnol. 2024 Dec;90:103216. doi: 10.1016/j.copbio.2024.103216. Epub 2024 Oct 21.
6
Single-cell transcriptomic sequencing analysis of mechanistic insights into the IFN-γ signaling pathway in different tumor cells.不同肿瘤细胞中IFN-γ信号通路机制洞察的单细胞转录组测序分析
Clin Transl Oncol. 2025 Feb;27(2):745-755. doi: 10.1007/s12094-024-03574-6. Epub 2024 Aug 1.
7
Expression of VISTA regulated via IFN-γ governs endogenous T-cell function and exhibits correlation with the efficacy of CD19 CAR-T cell treated B-malignant mice.IFN-γ 调控的 VISTA 表达控制内源性 T 细胞功能，并与 CD19 CAR-T 细胞治疗 B 恶性小鼠的疗效相关。
J Immunother Cancer. 2024 Jun 25;12(6):e008364. doi: 10.1136/jitc-2023-008364.
8
CAR affinity modulates the sensitivity of CAR-T cells to PD-1/PD-L1-mediated inhibition.嵌合抗原受体（CAR）亲和力调节 CAR-T 细胞对 PD-1/PD-L1 介导的抑制作用的敏感性。
Nat Commun. 2024 Apr 26;15(1):3552. doi: 10.1038/s41467-024-47799-z.
9
Integrative analysis of senescence-related genes identifies robust prognostic clusters with distinct features in hepatocellular carcinoma.衰老相关基因的综合分析确定了肝细胞癌中具有不同特征的强大预后聚类。
J Adv Res. 2025 Mar;69:107-123. doi: 10.1016/j.jare.2024.04.007. Epub 2024 Apr 14.
10
FOXO1 enhances CAR T cell stemness, metabolic fitness and efficacy.FOXO1 增强 CAR T 细胞干性、代谢适应性和疗效。
Nature. 2024 May;629(8010):201-210. doi: 10.1038/s41586-024-07242-1. Epub 2024 Apr 10.
N Engl J Med. 2016 Sep 1;375(9):819-29. doi: 10.1056/NEJMoa1604958. Epub 2016 Jul 13.
4
Driving CAR T-cells forward.推动嵌合抗原受体T细胞（CAR T细胞）向前发展。
Nat Rev Clin Oncol. 2016 Jun;13(6):370-83. doi: 10.1038/nrclinonc.2016.36. Epub 2016 Mar 22.
5
Intercellular adhesion molecule-1-dependent stable interactions between T cells and dendritic cells determine CD8+ T cell memory.T细胞与树突状细胞之间依赖细胞间黏附分子-1的稳定相互作用决定了CD8+ T细胞记忆。
Immunity. 2008 Feb;28(2):258-70. doi: 10.1016/j.immuni.2007.12.016.
6
Surface expression of the IFN-gamma R2 chain is regulated by intracellular trafficking in human T lymphocytes.干扰素-γ R2链的表面表达受人类T淋巴细胞内吞作用的调控。
J Immunol. 2000 Jan 1;164(1):201-7. doi: 10.4049/jimmunol.164.1.201.