Özkan Hüseyin Murat
Turk Psikiyatri Derg. 2020 Winter;31(4):294-296. doi: 10.5080/u23918.
Duloxetine is a serotonin-noradrenaline reuptake inhibitor (SNRI). The noradrenergic effects contribute to the treatment of painful physical symptoms. Hyperprolactinaemia and galactorrhea are recognized side effects of psychotropic drugs used in the treatment of psychiatric diseases. Although hyperprolactinaemia is a known side effect of the tricyclic antidepressants, evidence on hyperprolactinaemia and galactorrhoea induced by the selective serotonin reuptake inhibitors (SSRIs) and the SNRIs is limited. Hyperprolactinaemia due to SSRI or SNRI therapy is usually asymptomatic and is diagnosed after a detailed examination of the patient following the emergence of galactorrhea. In this report, a case who developed amenorrhea, galactorrhea, and hyper-prolactinaemia identified at the 5th month of duloxetine for major depression will be discussed. After a month of drug-free period and cabergoline treatment, the prolactin levels returned to normal.
度洛西汀是一种5-羟色胺-去甲肾上腺素再摄取抑制剂（SNRI）。去甲肾上腺素能效应有助于治疗疼痛的躯体症状。高泌乳素血症和溢乳是用于治疗精神疾病的精神药物公认的副作用。虽然高泌乳素血症是三环类抗抑郁药已知的副作用，但关于选择性5-羟色胺再摄取抑制剂（SSRI）和SNRI引起高泌乳素血症和溢乳的证据有限。SSRI或SNRI治疗引起的高泌乳素血症通常无症状，在患者出现溢乳后经过详细检查才得以诊断。在本报告中，将讨论1例在使用度洛西汀治疗重度抑郁症第5个月时出现闭经、溢乳和高泌乳素血症的病例。经过1个月的停药期和卡麦角林治疗后，泌乳素水平恢复正常。
