Oral Diagnosis Department, Piracicaba Dental School, Universidade Estadual de Campinas, Piracicaba, SP, Brazil.
Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
J Oral Pathol Med. 2021 Sep;50(8):741-749. doi: 10.1111/jop.13159. Epub 2021 Feb 18.
The aim of the present systematic review was to analyze the available data regarding acinic cell carcinoma of the oral and maxillofacial region.
A search strategy was performed using PubMed, Web of Science, Scopus, and Embase electronic databases.
Available data revealed a slight female preference (54.73%) and a mean age at diagnosis of 47.51 ± 19.85 years. The parotid glands (67.72%) were most frequently affected, and most cases were asymptomatic (69.54%). A microcystic histopathological pattern was reported in 21.56% of the cases, and the Periodic acid-Schiff was the staining method most frequently used, after the hematoxylin and eosin staining, in the tumors analyzed. The lesions were mainly treated by surgical removal (72.32%). Recurrence was reported in 81 cases (27.83%) and metastasis in 100 (42.91%). Statistical data analysis revealed that tumors located in major salivary glands and exhibiting high-grade histology were associated with local recurrence (P = .01). In addition, the patients older than 57 years, lesions with bone involvement, the high-grade tumors and the cases with a history of recurrence and metastasis were associated with a lower overall survival (P < .05).
By assembling all eligible cases in the literature, the present systematic review determined the most common clinicopathological profile of acinic cell carcinoma and the most relevant prognostic factors in a distinctly representative sample. The survey demonstrated the importance of considering the histopathological grading in order to better define the treatment for each case.
本系统评价的目的是分析关于口腔颌面部涎腺腺样囊性癌的现有数据。
使用 PubMed、Web of Science、Scopus 和 Embase 电子数据库进行检索策略。
现有数据显示，女性略占优势（54.73%），平均诊断年龄为 47.51±19.85 岁。腮腺（67.72%）最常受累，大多数病例无症状（69.54%）。21.56%的病例报告有微囊状组织病理学模式，过碘酸雪夫（Periodic acid-Schiff）染色是分析肿瘤时最常使用的染色方法，仅次于苏木精和伊红染色。病变主要通过手术切除（72.32%）进行治疗。81 例（27.83%）报告复发，100 例（42.91%）报告转移。统计数据分析显示，位于大涎腺且具有高级别组织学的肿瘤与局部复发相关（P=.01）。此外，年龄大于 57 岁、有骨侵犯的病变、高级别肿瘤以及有复发和转移史的病例与总体生存率降低相关（P<.05）。
通过汇集文献中所有合格病例，本系统评价确定了涎腺腺样囊性癌最常见的临床病理特征和在代表性样本中最相关的预后因素。该调查表明，考虑组织病理学分级对于更好地定义每个病例的治疗非常重要。
