Department of Experimental Medicine, University of Lleida-Lleida Biomedical Research Institute (UdL-IRBLleida), Lleida, Spain.
Department of Genetics, Physiology and Microbiology, Complutense University of Madrid, Madrid, Spain.
FEBS J. 2021 Dec;288(23):6652-6673. doi: 10.1111/febs.15714. Epub 2021 Feb 11.
Complex I, a component of the electron transport chain, plays a central functional role in cell bioenergetics and the biology of free radicals. The structural and functional N module of complex I is one of the main sites of the generation of free radicals. The NDUFV2 subunit/N1a cluster is a component of this module. Furthermore, the rate of free radical production is linked to animal longevity. In this review, we explore the hypothesis that NDUFV2 is the only conserved core subunit designed with a regulatory function to ensure correct electron transfer and free radical production, that low gene expression and protein abundance of the NDUFV2 subunit is an evolutionary adaptation needed to achieve a longevity phenotype, and that these features are determinants of the lower free radical generation at the mitochondrial level and a slower rate of aging of long-lived animals.
复合体 I 是电子传递链的一个组成部分，在细胞生物能量学和自由基生物学中起着核心功能作用。复合体 I 的结构和功能 N 模块是自由基产生的主要部位之一。NDUFV2 亚基/N1a 簇是该模块的一个组成部分。此外，自由基的产生速度与动物的寿命有关。在这篇综述中，我们探讨了这样一个假设，即 NDUFV2 是唯一具有调节功能的保守核心亚基，旨在确保正确的电子传递和自由基产生，而 NDUFV2 亚基的低基因表达和低蛋白丰度是实现长寿表型所必需的进化适应，这些特征决定了线粒体水平较低的自由基生成和长寿动物较慢的衰老速度。
