Hess F, Willemen A, Jerusalem C
Eur Surg Res. 1977;9(4):270-9. doi: 10.1159/000127946.
To evaluate the influence of the functional state of the recipient's liver on the fate of an auxiliary liver graft in rats, diverse surgical interventions were carried out on the recipient's liver following transplantation of an auxiliary liver. All grafts consisted of 30% of the liver mass, were supplied with portal blood only, and provided with bile drainage. Permanent graft hypertrophy was observed when the recipient's liver was resected subtotally, in addition to the ligation of the bile duct. Ligation of the bile duct performed separately has a more pronounced effect on the increase of the weight of the graft than subtotal hepotectomy. If only portal blood was deviated to the graft, grafts atrophied. It is concluded that the functional efficiency and condition of the graft vary directly with the degree of functional impairment of the recipient's liver, compair functional hypertrophy. The present results do not seem to indicate the presence of a specific hepatotrophic factor in portal blood.
为评估受体肝脏功能状态对大鼠辅助性肝移植移植物转归的影响，在辅助性肝移植后对受体肝脏进行了多种外科干预。所有移植物均由30%的肝脏组织构成，仅接受门静脉血供，并进行胆汁引流。当受体肝脏除胆管结扎外还进行次全切除时，观察到移植物出现永久性肥大。单独进行胆管结扎对移植物重量增加的影响比次全肝切除更为显著。若仅将门静脉血分流至移植物，则移植物萎缩。结论是，移植物的功能效率和状况与受体肝脏功能损害程度直接相关，呈现功能性肥大。目前的结果似乎并未表明门静脉血中存在特定的促肝细胞生长因子。
