Hess F, Willemen A, Jerusalem C
Eur Surg Res. 1978;10(6):444-55. doi: 10.1159/000128036.
After auxiliary liver transplantation in the rat, partial liver grafts (30% of the liver) were perfused with mesentericosplenic venous blood. This means a decrease in the total liver blood flow by approximately 34%. Recipient livers retained their arterial and pancreaticoduodenal inflow. Surgical interventions were carried out on the recipient's liver to evaluate the effect of the varying induced functional handicap on the fate of the graft in association with a decreased liver blood flow. Graft survival was obtained in all groups, but the conditions of the graft varied inversely with the severity of the functional handicap of the recipient's liver. Compared to previous experiments in which the auxiliary grafts were supplied with total portal blood inflow in the same experimental model, the grafts in this study showed a slightly impaired increase in weight. This impairment was attributed to the decreased blood flow. Recipient livers deteriorated or just maintained their size, even after 70% hepatectomy, despite the pancreaticoduodenal venous and arterial inflow. These results suggest that the total liver blood flow in combination with the functional state of the remaining recipient liver, rather than the quality of venous blood deriving from certain splanchnic areas and/or peculiar factor convoyed with it, determines the survival of a liver graft.
在大鼠进行辅助性肝移植后，部分肝移植物（占肝脏的30%）用肠系膜脾静脉血进行灌注。这意味着肝脏总血流量减少了约34%。受体肝脏保留其动脉和胰十二指肠血流。对受体肝脏进行手术干预，以评估不同程度的功能性障碍与肝脏血流减少相关联时对移植物命运的影响。所有组均获得了移植物存活，但移植物的状况与受体肝脏功能性障碍的严重程度呈反比。与之前在同一实验模型中辅助移植物接受全部门静脉血流供应的实验相比，本研究中的移植物重量增加略有受损。这种损害归因于血流减少。尽管有胰十二指肠静脉和动脉血流，受体肝脏即使在70%肝切除术后仍会恶化或仅维持其大小。这些结果表明，肝脏总血流量与剩余受体肝脏的功能状态共同决定了肝移植物的存活，而非源自某些内脏区域的静脉血质量和/或伴随的特殊因素。
