Hess F, Jerusalem C, Polak M
Eur Surg Res. 1976;8(2):156-65. doi: 10.1159/000127857.
The risk of azathioprine-induced hepatocellular damage was investigated using the auxiliary liver transplantation model in rats. This model permits to study the effect of the drug on both graft and the recipient's liver vascularized in different ways. Neither histopathological changes were observed, nor could any deaths be directly attributed to toxic effects of the drug on hepatocytes. Morphological lesions were absent in treated and untreated, subtotally hepatectomized rats with normal bile flow. However, lesions did become manifest after reimplantation (grafts) and/or ligation of the common bile duct (hosts). We concluded that in rats azathioprine is toxic for hepatocytes only when the normal bile flow is impeded, independent of the way of the liver vascularization.
使用大鼠辅助肝移植模型研究了硫唑嘌呤诱导肝细胞损伤的风险。该模型允许研究药物对以不同方式血管化的移植物和受体肝脏的影响。既未观察到组织病理学变化，也没有任何死亡可直接归因于药物对肝细胞的毒性作用。在胆汁流动正常的经治疗和未经治疗的次全肝切除大鼠中未出现形态学损伤。然而，在再植入（移植物）和/或结扎胆总管（宿主）后损伤确实显现出来。我们得出结论，在大鼠中，只有当正常胆汁流动受阻时，硫唑嘌呤才对肝细胞有毒性，与肝脏血管化方式无关。
