Department of Oncology, Faculty of Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
J BUON. 2020 Nov-Dec;25(6):2700-2707.
Tumor infiltrating lymphocytes (TILs) in cutaneous malignant melanoma are classified as brisk, non-brisk or absent. Numerous studies suggest the presence of TILs, especially brisk, are associated with a lower rate of lymph node metastasis and with an improved overall survival (OS). Our purpose was to assess the value of TILs as a prognostic factor for the lymph node metastasis and survival in completely resected pT3 stage malignant melanoma patients.
We included a number of 114 patients with pathological pT3 cutaneous malignant melanoma, treated exclusively in our institution, between 2000-2015. Correlations of clinical and pathological factors with lymph node status and OS were analyzed.
A brisk infiltrate was present in 60% of the patients, whereas 40% presented a non-brisk infiltrate or absent TILs. In univariate analysis, the presence of ulceration was correlated with a non-brisk infiltrate, whereas in multivariate analysis, lymph node invasion and a non-brisk infiltrate were associated with a higher risk of death.
TILs density grade represents an independent prognostic factor for the OS. Therefore, we conclude that an accurate prognosis may be provided by TILs status in patients with pT3 malignant melanoma.
皮肤恶性黑色素瘤中的肿瘤浸润淋巴细胞（TILs）分为活跃型、非活跃型或缺失型。许多研究表明，TILs 的存在，尤其是活跃型，与较低的淋巴结转移率和更好的总生存率（OS）相关。我们的目的是评估 TILs 作为完全切除的 pT3 期恶性黑色素瘤患者淋巴结转移和生存的预后因素的价值。
我们纳入了 2000 年至 2015 年间在我们机构治疗的病理 pT3 皮肤恶性黑色素瘤患者 114 例。分析了临床和病理因素与淋巴结状态和 OS 的相关性。
60%的患者存在活跃浸润，40%的患者存在非活跃浸润或缺乏 TILs。在单因素分析中，溃疡与非活跃浸润有关，而在多因素分析中，淋巴结侵犯和非活跃浸润与更高的死亡风险相关。
TILs 密度分级是 OS 的独立预后因素。因此，我们得出结论，TILs 状态可为 pT3 恶性黑色素瘤患者提供准确的预后。
