Baek Wooyeol, Kim Min Sup, Park Dan Bi, Joo Oh Young, Lee Won Jai, Roh Tai Suk, Sung Hak-Joon
Institute for Human Tissue Restoration, Department of Plastic & Reconstructive Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Korea.
PLCOSKIN Inc., Seoul 120-752, Korea.
ACS Biomater Sci Eng. 2019 Oct 14;5(10):4962-4969. doi: 10.1021/acsbiomaterials.9b00985. Epub 2019 Sep 30.
Significant fat loss is common in silicon implantation with autologous lipofilling, the most popular type of breast surgery. To overcome this, a 3D-printed fat carrier with well-defined 200 μm radial string and spoke structure was developed, followed by an electrospun nanofiber coating on the entire device surface to promote fat adhesion. This device enhanced the mechanical properties comparably to commercial acellular dermal matrix for adipogenic differentiation of adipose-derived stem cells, implantation compatibility without foreign body responses, and maintenance of healthy lipid droplet structures. These results show the promising potential of this device to facilitate surface-guided lipogenesis in composite breast reconstruction surgery.
在最常见的乳房手术——自体脂肪填充硅植入术中，显著的脂肪流失很常见。为了克服这一问题，研发了一种具有明确的200μm径向弦和辐条结构的3D打印脂肪载体，随后在整个装置表面进行电纺纳米纤维涂层以促进脂肪附着。该装置增强了机械性能，与用于脂肪来源干细胞成脂分化的商业脱细胞真皮基质相当，具有植入兼容性且无异物反应，并能维持健康的脂滴结构。这些结果表明该装置在复合乳房重建手术中促进表面引导脂肪生成方面具有广阔的应用前景。
