Miguel Servet Ophthalmology Research and Innovative Group (GIMSO), Aragon Institute for Health Research (IIS Aragón), University of Zaragoza, Zaragoza, Spain.
Ophthalmology Department, Miguel Servet University Hospital, Zaragoza, Spain.
Curr Eye Res. 2021 Aug;46(8):1214-1222. doi: 10.1080/02713683.2021.1877313. Epub 2021 Jan 31.
Twenty-five eyes of 25 patients with bipolar disorder and 74 eyes of 74 healthy controls underwent retinal measurements of retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) thickness. Measurements were obtained using the Spectralis-OCT device with the new Posterior Pole protocol which assesses the macular area by analyzing retinal thickness in a grid of 64 (8*8) cells.
Significant differences ( < 0.05) in RNFL and GCL thickness were found between BD patients and healthy controls, in parafoveal and perifoveal cells respectively. Significant inverse correlations were found between RNFL and GCL thinning at their thickest location and the duration of bipolar disorder. Several predictive variables were observed with a binary logistic regression for the presence/absence of BD: cell 1.3 RNFL ( = 0.028) and GCL in cells 7.8 ( = 0.012), 2.7 ( = 0.043) and 1.3 ( = 0.047).
Posterior Pole OCT protocol is a useful tool to assess changes in the inner retinal layers in bipolar disorder. These observed changes, especially those affecting the GCL, may be associated with disease evolution and may be predictive of the presence of the disease. OCT data could potentially be a useful tool for clinicians to diagnose and monitor BD patients.
25 名双相情感障碍患者的 25 只眼和 74 名健康对照者的 74 只眼接受了视网膜神经纤维层（RNFL）和节细胞层（GCL）厚度的视网膜测量。使用 Spectralis-OCT 设备和新的后极方案进行测量，该方案通过分析视网膜厚度网格中的 64 个（8*8）细胞来评估黄斑区域。
在旁中心和中心凹旁区域，BD 患者和健康对照组之间的 RNFL 和 GCL 厚度存在显著差异（<0.05）。在最厚部位的 RNFL 和 GCL 变薄与双相情感障碍的持续时间之间存在显著的负相关。通过二元逻辑回归观察到几个预测变量与 BD 的存在/不存在有关：细胞 1.3 RNFL（=0.028）和细胞 7.8、2.7 和 1.3 的 GCL（=0.012、0.043 和 0.047）。
后极 OCT 方案是评估双相情感障碍患者内层视网膜变化的有用工具。这些观察到的变化，特别是那些影响 GCL 的变化，可能与疾病的演变有关，并可能预示着疾病的存在。OCT 数据可能是临床医生诊断和监测 BD 患者的有用工具。
