Department of Biomedical Engineering, School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, China.
Department of Biomedical Engineering, Army Medical University, 30 Gaotanyan Street, Shapingba District, Chongqing, 400038, China.
BMC Neurol. 2021 Jan 18;21(1):26. doi: 10.1186/s12883-021-02049-3.
To investigate the feasibility of intracranial pressure (ICP) monitoring after traumatic brain injury (TBI) by electromagnetic coupling phase sensing, we established a portable electromagnetic coupling phase shift (ECPS) test system and conducted a comparison with invasive ICP.
TBI rabbits' model were all synchronously monitored for 24 h by ECPS testing and invasive ICP. We investigated the abilities of the ECPS to detect targeted ICP by feature extraction and traditional classification decision algorithms.
The ECPS showed an overall downward trend with a variation range of - 13.370 ± 2.245° as ICP rose from 11.450 ± 0.510 mmHg to 38.750 ± 4.064 mmHg, but its change rate gradually declined. It was greater than 1.5°/h during the first 6 h, then decreased to 0.5°/h and finally reached the minimum of 0.14°/h. Nonlinear regression analysis results illustrated that both the ECPS and its change rate decrease with increasing ICP post-TBI. When used as a recognition feature, the ability (area under the receiver operating characteristic curve, AUCs) of the ECPS to detect ICP ≥ 20 mmHg was 0.88 ± 0.01 based on the optimized adaptive boosting model, reaching the advanced level of current noninvasive ICP assessment methods.
The ECPS has the potential to be used for noninvasive continuous monitoring of elevated ICP post-TBI.
为了研究电磁耦合相位感应（ECPS）技术在创伤性脑损伤（TBI）后颅内压（ICP）监测中的可行性，我们建立了一种便携式电磁耦合相移（ECPS）测试系统，并与有创 ICP 进行了比较。
TBI 兔模型同步通过 ECPS 测试和有创 ICP 监测 24 h。我们通过特征提取和传统分类决策算法研究了 ECPS 检测目标 ICP 的能力。
ECPS 随着 ICP 从 11.450±0.510 mmHg 升高到 38.750±4.064 mmHg 呈整体下降趋势，变化范围为-13.370±2.245°，但变化率逐渐下降。在前 6 h 内大于 1.5°/h，然后降至 0.5°/h，最后达到最小的 0.14°/h。非线性回归分析结果表明，ECPS 及其变化率均随 post-TBI ICP 的增加而降低。当用作识别特征时，ECPS 检测 ICP≥20 mmHg 的能力（基于优化自适应增强模型的受试者工作特征曲线下面积，AUCs）为 0.88±0.01，达到了当前非侵入性 ICP 评估方法的先进水平。
ECPS 有潜力用于 post-TBI 时的非侵入性连续监测升高的 ICP。
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