Zink B J, Dronen S C, Syverud S A
Department of Emergency Medicine, University of Cincinnati Medical Center, OH 45219.
Circ Shock. 1988;24(1):19-28.
Ethanol has been reported to cause myocardial suppression, exaggerated hypotension, and increased mortality in various animal models of hemorrhagic shock. Previous studies have not used a fixed-volume graded hemorrhage model and have not monitored cardiac output or metabolic parameters such as serum glucose and lactate levels. We studied hemodynamic and metabolic changes after administration of ethanol in a 50% graded hemorrhage model in conditioned, anesthetized beagles after orogastric ethanol loading. The hemorrhage was done over a 60-min period followed by a 90-min stabilization period. The ethanol group (n = 6) had significantly higher heart rates during the stabilization period. Mean arterial pressures (MAP) were lower in the ethanol group during the stabilization period. The change from baseline MAP 30 min after hemorrhage was -31% in the control group and -53% in the ethanol group (P less than .05 using Wilcoxon ranked sum test). Serum glucose and lactate levels were higher in the ethanol group. These results indicate that ethanol impairs hemodynamics and alters glucose and lactate metabolism in dogs in the fixed-volume graded hemorrhage model. The effect of these changes on morbidity and mortality remains to be determined.
据报道，在各种失血性休克动物模型中，乙醇会导致心肌抑制、严重低血压并增加死亡率。以往的研究未采用固定容量分级出血模型，也未监测心输出量或代谢参数，如血糖和乳酸水平。我们在经条件驯化、麻醉的比格犬中，通过口胃管给予乙醇后，在50%分级出血模型中研究了乙醇给药后的血流动力学和代谢变化。出血过程持续60分钟，随后是90分钟的稳定期。乙醇组（n = 6）在稳定期的心率显著更高。乙醇组在稳定期的平均动脉压（MAP）较低。出血后30分钟，对照组MAP较基线的变化为-31%，乙醇组为-53%（使用Wilcoxon秩和检验，P小于0.05）。乙醇组的血糖和乳酸水平更高。这些结果表明，在固定容量分级出血模型中，乙醇会损害犬的血流动力学，并改变葡萄糖和乳酸代谢。这些变化对发病率和死亡率的影响仍有待确定。
