Department of Pulmonology, Ningbo Yinzhou No 2. Hospital.
Cixi People's Hospital of Zhejiang Province.
J Nippon Med Sch. 2021 Sep 1;88(4):319-325. doi: 10.1272/jnms.JNMS.2021_88-410. Epub 2021 Jan 16.
The study aimed to identify risk factors associated with overall survival (OS) of patients with lung adenocarcinoma (LACA) with brain metastasis and developed a prognostic tool (nomogram) for these patients.
LACA patients with brain metastases between 2010 and 2013 were selected from the Surveillance, Epidemiology, and End Results (SEER) database. Kaplan-Meier analysis and a Cox regression model were used to assess the prognostic effect of variables on survival rate. A nomogram was developed to predict 3-, 6- and 9-month OS rates.
2,631 LACA patients with brain metastases were studied. A nomogram was developed by using variables that affected OS and was validated by internal bootstrap resampling, which revealed that the nomogram had satisfactory discrimination.
The nomogram was able to predict 3-, 6- and 9-month OS for patients with LACA and brain metastases.
本研究旨在确定与肺腺癌（LACA）伴脑转移患者总生存（OS）相关的风险因素，并为这些患者开发一种预后工具（列线图）。
从监测、流行病学和最终结果（SEER）数据库中选择 2010 年至 2013 年间患有脑转移的 LACA 患者。采用 Kaplan-Meier 分析和 Cox 回归模型评估变量对生存率的预后影响。建立列线图预测 3、6 和 9 个月的 OS 率。
研究了 2631 例患有脑转移的 LACA 患者。通过使用影响 OS 的变量开发了一个列线图，并通过内部自举重采样进行了验证，结果表明该列线图具有良好的区分度。
该列线图能够预测 LACA 伴脑转移患者 3、6 和 9 个月的 OS。
