肺腺癌脑转移患者的预后因素和生存预测。
Prognostic Factors and Prediction of Survival for Patients with Brain Metastases of Lung Adenocarcinoma.
机构信息
Department of Pulmonology, Ningbo Yinzhou No 2. Hospital.
Cixi People's Hospital of Zhejiang Province.
出版信息
J Nippon Med Sch. 2021 Sep 1;88(4):319-325. doi: 10.1272/jnms.JNMS.2021_88-410. Epub 2021 Jan 16.
BACKGROUND
The study aimed to identify risk factors associated with overall survival (OS) of patients with lung adenocarcinoma (LACA) with brain metastasis and developed a prognostic tool (nomogram) for these patients.
METHODS
LACA patients with brain metastases between 2010 and 2013 were selected from the Surveillance, Epidemiology, and End Results (SEER) database. Kaplan-Meier analysis and a Cox regression model were used to assess the prognostic effect of variables on survival rate. A nomogram was developed to predict 3-, 6- and 9-month OS rates.
RESULTS
2,631 LACA patients with brain metastases were studied. A nomogram was developed by using variables that affected OS and was validated by internal bootstrap resampling, which revealed that the nomogram had satisfactory discrimination.
CONCLUSIONS
The nomogram was able to predict 3-, 6- and 9-month OS for patients with LACA and brain metastases.
背景
本研究旨在确定与肺腺癌（LACA）伴脑转移患者总生存（OS）相关的风险因素，并为这些患者开发一种预后工具（列线图）。
方法
从监测、流行病学和最终结果（SEER）数据库中选择 2010 年至 2013 年间患有脑转移的 LACA 患者。采用 Kaplan-Meier 分析和 Cox 回归模型评估变量对生存率的预后影响。建立列线图预测 3、6 和 9 个月的 OS 率。
结果
研究了 2631 例患有脑转移的 LACA 患者。通过使用影响 OS 的变量开发了一个列线图，并通过内部自举重采样进行了验证，结果表明该列线图具有良好的区分度。
结论
该列线图能够预测 LACA 伴脑转移患者 3、6 和 9 个月的 OS。
Zotero 插件