Department of Preventive Medicine and Public Health, Keio University School of Medicine.
Department of Public Health, Hokkaido University Faculty of Medicine.
J Epidemiol. 2022 Jul 5;32(7):303-313. doi: 10.2188/jea.JE20200399. Epub 2021 Jun 22.
Non-fasting triglycerides (TG) are considered a better predictor of cardiovascular disease (CVD) than fasting TG. However, the effect of non-fasting TG on fatal CVD events remains unclear. In the present study, we aimed to explore the relationship between non-fasting TG and CVD mortality in a Japanese general population.
A total of 6,831 participants without a history of CVD, in which those who had a blood sampling over 8 hours or more after a meal were excluded, were followed for 18.0 years. We divided participants into seven groups according to non-fasting TG levels: ≤59 mg/dL, 60-89 mg/dL, 90-119 mg/dL, 120-149 mg/dL, 150-179 mg/dL, 180-209 mg/dL, and ≥210 mg/dL, and estimated the multivariable-adjusted hazard ratios (HRs) of each TG group for CVD mortality after adjusting for potential confounders, including high density lipoprotein cholesterol. Additionally, we performed analysis stratified by age <65 and ≥65 years.
During the follow-up period, 433 deaths due to CVD were detected. Compared with a non-fasting TG of 150-179 mg/dL, non-fasting TG ≥210 mg/dL was significantly associated with increased risk for CVD mortality (HR 1.56: 95% CI, 1.01-2.41). Additionally, lower levels of non-fasting TG were also significantly associated with increased risk for fatal CVD. In participants aged ≥65 years, lower levels of non-fasting TG had a stronger impact on increased risk for CVD mortality, while higher levels of non-fasting TG had a stronger impact in those aged <65 years.
In a general Japanese population, we observed a U-shaped association between non-fasting TG and fatal CVD events.
非空腹甘油三酯（TG）被认为比空腹 TG 更能预测心血管疾病（CVD）。然而，非空腹 TG 对致命 CVD 事件的影响尚不清楚。在本研究中，我们旨在探讨日本一般人群中非空腹 TG 与 CVD 死亡率之间的关系。
共有 6831 名无 CVD 病史的参与者，其中排除了餐后采血 8 小时以上的参与者，随访时间为 18.0 年。我们根据非空腹 TG 水平将参与者分为七组：≤59mg/dL、60-89mg/dL、90-119mg/dL、120-149mg/dL、150-179mg/dL、180-209mg/dL 和≥210mg/dL，并调整了高密度脂蛋白胆固醇等潜在混杂因素后，估计每个 TG 组的 CVD 死亡率的多变量调整后的危险比（HR）。此外，我们还按年龄<65 岁和≥65 岁进行了分层分析。
在随访期间，检测到 433 例 CVD 死亡。与非空腹 TG 为 150-179mg/dL 相比，非空腹 TG≥210mg/dL 与 CVD 死亡率增加显著相关（HR 1.56：95%CI，1.01-2.41）。此外，非空腹 TG 水平较低也与致命 CVD 的风险增加显著相关。在年龄≥65 岁的参与者中，非空腹 TG 水平较低对 CVD 死亡率增加的影响更强，而在年龄<65 岁的参与者中，非空腹 TG 水平较高对 CVD 死亡率增加的影响更强。
在日本一般人群中，我们观察到非空腹 TG 与致命 CVD 事件之间呈 U 形关联。
