Department of Cardiovascular Medicine, Fukushima Medical University, Japan.
Department of Pulmonary Hypertension, Fukushima Medical University, Japan.
Intern Med. 2021;60(2):201-208. doi: 10.2169/internalmedicine.5422-20. Epub 2021 Jan 15.
Objective It has been reported that anti-mitochondrial antibodies (AMAs) recognize mitochondrial antigens and are associated with some diseases involving multiple organs, such as primary biliary cholangitis, Sjögren syndrome, Hashimoto's thyroiditis, systemic sclerosis, interstitial pneumoniae, dilated cardiomyopathy, and tubulointerstitial nephritis. In the current study, we examined the prevalence of AMAs in patients with dilated cardiomyopathy (DCM) and their clinical characteristics. Methods We enrolled 270 patients with DCM. We measured serum AMAs and analyzed the associated factors. Out of the 270 patients, positive AMAs were detected in 3 patients (1.1%; mean age, 68 years old; 2 men). These three patients had a significantly higher prevalence of primary biliary cholangitis and myopathy and levels of alanine alkaline phosphatase than those who were negative for said antibodies. There were no significant differences in the levels of B-type natriuretic peptide, aspartate transaminase, and left ventricular ejection fraction between these groups of patients. During the follow-up period, two of the three patients died due to respiratory failure. The other patient survived but experienced type II respiratory failure. Conclusion The prevalence of AMAs in 270 DCM patients was only 1.1%, and these patients suffered from respiratory failure.
据报道，抗线粒体抗体（AMAs）可识别线粒体抗原，并与一些涉及多个器官的疾病相关，如原发性胆汁性胆管炎、干燥综合征、桥本甲状腺炎、系统性硬化症、间质性肺炎、扩张型心肌病和肾小管间质性肾炎。在本研究中，我们检测了扩张型心肌病（DCM）患者AMA 的患病率及其临床特征。
我们纳入了 270 例 DCM 患者。我们测量了血清 AMA，并分析了相关因素。在 270 例患者中，有 3 例（1.1%；平均年龄 68 岁；2 名男性）AMA 阳性。这 3 例患者原发性胆汁性胆管炎和肌病的患病率以及丙氨酸碱性磷酸酶水平显著高于 AMA 阴性患者。这些患者的 B 型利钠肽、天门冬氨酸转氨酶和左心室射血分数水平无显著差异。在随访期间，这 3 例患者中有 2 例因呼吸衰竭而死亡。另一位患者存活，但出现 II 型呼吸衰竭。
在 270 例 DCM 患者中，AMA 的患病率仅为 1.1%，且这些患者发生了呼吸衰竭。
