活动性炎症和手术治疗在克罗恩病复发中的作用。
The Role of Active Inflammation and Surgical Therapy in Crohn's Disease Recurrence.
作者信息
Ingallinella S, Campanelli M, Antonelli A, Arcudi C, Bellato V, Divizia A, Franceschilli M, Petagna L, Sensi B, Sibio S, Siragusa L, Sica G S
机构信息
Department of Surgery, Tor Vergata University of Rome, Viale Oxford 81, 00133 Rome, Italy.
Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia (UNIMO), Modena, Italy.
出版信息
Gastroenterol Res Pract. 2020 Dec 28;2020:2845407. doi: 10.1155/2020/2845407. eCollection 2020.
An altered balance between effector and regulatory factors is supposed to sustain the tissue-damaging immune response in inflammatory bowel disease (IBD). Several studies demonstrate that severe active inflammation is a strong predictor for surgical complications and recurrence. Indeed, bowel resection in Crohn's disease (CD) patients has a high surgical recurrence rate. In this review, we examined the IBD inflammatory pathways, the current surgical treatments, and the almost inevitable recurrence. The question that might arise is if the cure of intestinal CD is to be found in the surgical approach. A selective search of two databases (PubMed and the Cochrane Library) has been carried out without considering a specific time horizon as inclusion criteria. The scope of this literature review was investigating on the role of inflammation in the management of CD. The following key words have been used to develop the query string: () inflammation; () Crohn's disease; () surgery; and () postsurgical recurrence.
效应因子与调节因子之间平衡的改变被认为维持了炎症性肠病（IBD）中损害组织的免疫反应。多项研究表明，严重的活动性炎症是手术并发症和复发的有力预测指标。事实上，克罗恩病（CD）患者的肠切除术具有较高的手术复发率。在本综述中，我们研究了IBD的炎症途径、当前的手术治疗方法以及几乎不可避免的复发情况。可能出现的问题是，肠道CD的治愈方法是否能在手术治疗中找到。我们对两个数据库（PubMed和Cochrane图书馆）进行了选择性检索，未将特定的时间范围作为纳入标准。这篇文献综述的范围是研究炎症在CD治疗中的作用。以下关键词用于构建检索词：（）炎症；（）克罗恩病；（）手术；以及（）术后复发。
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