用于多种核素微球研究的计算机化剥离方法

Computerized stripping method for multiple nuclide microsphere studies.

作者信息

Irion G L, Wolfson M R, Alsberge M S

机构信息

Department of Physiology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298.

出版信息

Comput Biomed Res. 1988 Feb;21(1):27-37. doi: 10.1016/0010-4809(88)90039-0.

DOI:10.1016/0010-4809(88)90039-0

PMID:3345650

Abstract

Radiolabeled microspheres are commonly used to measure cardiac output and regional blood flow distribution in small animals such as rats. By using batches of microspheres labeled with different nuclides, several flow measurements can be made in the same animal. A protocol and computer program for analyzing data from multiple nuclide microsphere experiments are described. This protocol is designed to reduce the amount of arterial blood which must be withdrawn during microsphere distribution and eliminate the potential loss of data due to contamination of reference samples by nuclides used in previous flow measurements.

摘要

放射性标记微球常用于测量大鼠等小动物的心输出量和局部血流分布。通过使用标记有不同核素的多批微球，可以在同一只动物身上进行多次血流测量。本文描述了一种用于分析多核素微球实验数据的方案和计算机程序。该方案旨在减少微球分布过程中必须抽取的动脉血量，并消除由于先前血流测量中使用的核素污染参考样本而导致的数据潜在损失。