Kuwahira I, Gonzalez N C, Heisler N, Piiper J
Abteilung Physiologie, Max-Planck-Institut für experimentelle Medizin, Göttingen, Federal Republic of Germany.
J Appl Physiol (1985). 1993 Jan;74(1):211-4. doi: 10.1152/jappl.1993.74.1.211.
The effects of acute hypoxia on central hemodynamics, regional blood flow, and regional oxygen supply (blood flow x arterial O2 concentration) were studied in conscious resting rats. Regional blood flow was determined by the radiolabeled microsphere technique. Blood pressure, heart rate; and aortic blood flow increased and total peripheral resistance decreased significantly during hypoxia. Blood flow to brain, respiratory muscles, and liver increased both in absolute value and as a fraction of the aortic blood flow. Fractional blood flow to the gastrointestinal tract, spleen, pancreas, skin, fat, and hindlimb bones decreased during hypoxia; blood flow decreased in absolute values only in stomach and fat. Oxygen supply to brain, respiratory muscles, and liver increased during hypoxia, whereas it decreased in the remaining organs investigated.
在清醒的静息大鼠中研究了急性缺氧对中心血流动力学、局部血流和局部氧供（血流×动脉血氧浓度）的影响。局部血流通过放射性微球技术测定。缺氧期间，血压、心率和主动脉血流量增加，总外周阻力显著降低。脑、呼吸肌和肝脏的血流量绝对值增加，且占主动脉血流量的比例也增加。缺氧期间，胃肠道、脾脏、胰腺、皮肤、脂肪和后肢骨骼的血流量分数降低；仅胃和脂肪的血流量绝对值降低。缺氧期间，脑、呼吸肌和肝脏的氧供增加，而在其余研究的器官中氧供减少。
