Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Theranostics. 2021 Jan 1;11(6):2581-2593. doi: 10.7150/thno.52366. eCollection 2021.
Colorectal cancer (CRC) is one of the most prevalent cancers and one of the leading causes of cancer death. Recent studies have provided evidence that N-methyladenosine (mA), the most abundant RNA modifications in eukaryote, performs many functions in RNA metabolism including translation, splicing, storage, trafficking and degradation. Aberrant regulation of mA modification in mRNAs and noncoding RNAs found in CRC tissues is crucial for cancer formation, progression, invasion and metastasis. Further, mA regulators and mA-related RNAs may become promising biomarkers, prognosis predictors as well as therapeutic targets. Here, we review the biological and clinical roles of mA modification in CRC, and discuss the potential of mA in clinical translation.
结直肠癌（CRC）是最常见的癌症之一，也是癌症死亡的主要原因之一。最近的研究提供了证据，表明 N6-甲基腺苷（m6A），真核生物中最丰富的 RNA 修饰，在 RNA 代谢中发挥许多功能，包括翻译、剪接、储存、运输和降解。CRC 组织中 mRNA 和非编码 RNA 中 mA 修饰的异常调节对癌症的形成、进展、侵袭和转移至关重要。此外，mA 调节剂和 mA 相关 RNA 可能成为有前途的生物标志物、预后预测因子和治疗靶点。在这里，我们综述了 mA 修饰在 CRC 中的生物学和临床作用，并讨论了 mA 在临床转化中的潜力。
