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接触次氯酸钠后发生的机化性肺炎:一例报告

Organizing Pneumonia After Exposure to Sodium Hypochlorite: A Case Report.

作者信息

Santos Inês, Lucas Sandra, Seixas Rui, Lino Ireneia

机构信息

Internal Medicine, Hospital do Espírito Santo de Évora E.P.E, Largo Senhor da Pobreza, 7000-811, Évora, PRT.

出版信息

Cureus. 2020 Dec 11;12(12):e12025. doi: 10.7759/cureus.12025.

Abstract

Organizing pneumonia (OP) is a rare inflammatory lung disease with a difficult diagnosis and sparse mentions in the literature. In most cases, the etiology is unknown but may be associated with infections, systemic disorders, exposure to industrial toxins and environmental pollutants, or even drug toxicity. This report describes a 77-year-old male who presented to the hospital with nonproductive cough, myalgias, fever, and progressive weight loss after prolonged exposure to sodium hypochlorite. The patient was treated with multiple courses of antibiotics with no pathogen isolation. Chest CT revealed condensation foci of all pulmonary lobes. His clinical history, laboratory results, and CT images led to the diagnosis of OP, which was confirmed with a transbronchial lung biopsy. The patient was treated with oral prednisolone with clinical improvement and discharge one week after the beginning of the corticosteroid treatment. OP diagnosis can be challenging and, if not considered, may lead to a delay in providing appropriate treatment to the patients, which can often lead to a prolonged hospital stay and poor outcomes.

摘要

机化性肺炎(OP)是一种罕见的炎症性肺部疾病,诊断困难,文献中提及较少。在大多数情况下,病因不明,但可能与感染、全身性疾病、接触工业毒素和环境污染物,甚至药物毒性有关。本报告描述了一名77岁男性,在长期接触次氯酸钠后,因干咳、肌痛、发热和进行性体重减轻入院。患者接受了多疗程抗生素治疗,但未分离出病原体。胸部CT显示所有肺叶均有实变灶。他的临床病史、实验室检查结果和CT图像导致诊断为OP,经支气管肺活检得以确诊。患者接受口服泼尼松龙治疗,临床症状改善,在开始使用皮质类固醇治疗一周后出院。OP的诊断可能具有挑战性,如果不考虑到这一点,可能会导致延迟为患者提供适当的治疗,这往往会导致住院时间延长和预后不良。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0645/7797455/c5c221a3a80e/cureus-0012-00000012025-i01.jpg

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