Mohammadi Belgheis, Matinfar Marzieh, Drees Fatemeh, Shabanian Sheida
Department of Gynecology and Obstetrics, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Departments of Gynecology and Obstetrics, Student of Research Committee, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Adv Biomed Res. 2020 Sep 30;9:45. doi: 10.4103/abr.abr_27_20. eCollection 2020.
Intrauterine growth factor (IUGR) is one of the most important causes of neonatal mortality. The aim of this study was to evaluate the therapeutic effect of utrogestan on the treatment of IUGR and its complications.
In this clinical trial, 66 pregnant women with idiopathic IUGR embryos were enrolled. Patients in the intervention group, in addition to receiving routine treatment of control group (high-protein diet, resting), took utrogestan capsules (100 mg) twice daily. The primary and secondary outcomes of the disease were recorded in a checklist. Data were analyzed using SPSS 18 using an independent -test, Chi-square test, and Fisher's exact test.
In the intervention group, mean neonatal weight ( = 0.003), mean neonatal Apgar score ( = 0.001), and mean gestational age at birth ( = 0.001) were significantly higher than those in the control group. There was no neonatal death in the intervention group, whereas in the control group, four cases of neonatal death were observed ( = 0.03). In the majority of subjects in the intervention group, resistance index, and pulsatility index of the umbilical artery decreased ( = 0.002). The difference in abdominal circumference and gestational age in the intervention group decreased ( = 0.01). In the intervention group, the diastolic flow of the umbilical artery increased ( = 0.002).
Utrogestan was effective as an inexpensive and effective way to treat IUGR and improve pregnancy outcomes.
宫内生长受限（IUGR）是新生儿死亡的最重要原因之一。本研究的目的是评估天然黄体酮治疗IUGR及其并发症的疗效。
在这项临床试验中，纳入了66例患有特发性IUGR胚胎的孕妇。干预组患者除接受对照组的常规治疗（高蛋白饮食、休息）外，还每日服用两次天然黄体酮胶囊（100毫克）。疾病的主要和次要结局记录在检查表中。使用SPSS 18软件，采用独立样本t检验、卡方检验和Fisher精确检验对数据进行分析。
干预组新生儿平均体重（P = 0.003）、新生儿平均阿氏评分（P = 0.001）和出生时平均孕周（P = 0.001）均显著高于对照组。干预组无新生儿死亡，而对照组观察到4例新生儿死亡（P = 0.03）。干预组大多数受试者的脐动脉阻力指数和搏动指数降低（P = 0.002）。干预组腹围和孕周的差异减小（P = 0.01）。干预组脐动脉舒张期血流增加（P = 0.002）。
天然黄体酮是治疗IUGR并改善妊娠结局的一种经济有效的方法。
