Namlı Kalem Müberra, Kalem Ziya, Bakırarar Batuhan, Ergün Ali, Gürgan Timur
Clinic of Obstetrics and Gynecology, Liv Hospital, Ankara, Turkey.
Gürgan Clinic IVF and Women Health Center, Ankara, Turkey.
J Turk Ger Gynecol Assoc. 2018 Mar 1;19(1):29-33. doi: 10.4274/jtgga.2017.0056.
To evaluate the possible association between progesterone use in the first trimester of pregnancy and fetal nuchal translucency (NT).
This is an observational case-control study, which was conducted with patients who underwent nuchal scans between March 2015 and February 2016 and consequently delivered live and healthy babies. The study group was composed of assisted reproductive technology pregnancies and used intravaginal progesterone 180 mg/day until gestational week 12. The control group comprised pregnant women who became pregnant spontaneously without using any progesterone preparation in the first trimester.
One hundred sixty-four (57.5%) of 285 patients were in the control group and 121 (42.5%) were in the progesterone group. Age, bodyweight, gravidity, and parity number of previous births and abortus, gestational week, crown-rump lengths, free β-human chorionic gonadotropin, pregnancy-associated plasma protein A, and NT values of the progesterone and control groups were recorded and we investigated whether there was a statistically significant difference between the two groups in terms of these parameters; maternal weight was found to be higher in the progesterone group than in the control group and the difference between the groups was statistically significant (p=0.019 and p=0.025). Whether the difference in NT was caused by the effect of maternal weight was investigated using the covariance analysis test and maternal weight was not found to be statistically significant in the model (p=0.284).
Fetal NT was increased in the progesterone group compared with the untreated group in healthy pregnancies.
评估妊娠早期使用孕酮与胎儿颈部半透明带（NT）之间的可能关联。
这是一项观察性病例对照研究，研究对象为2015年3月至2016年2月期间接受颈部扫描并最终分娩出健康活婴的患者。研究组由接受辅助生殖技术妊娠的患者组成，在妊娠12周前每天经阴道使用180毫克孕酮。对照组包括妊娠早期自然受孕且未使用任何孕酮制剂的孕妇。
285例患者中，164例（57.5%）在对照组，121例（42.5%）在孕酮组。记录了孕酮组和对照组患者的年龄、体重、孕次、既往生育和流产次数、孕周、头臀长度、游离β-人绒毛膜促性腺激素、妊娠相关血浆蛋白A以及NT值，并调查了两组在这些参数方面是否存在统计学显著差异；发现孕酮组孕妇体重高于对照组，两组间差异具有统计学显著性（p = 0.019和p = 0.025）。使用协方差分析检验调查NT差异是否由孕妇体重影响所致，结果发现孕妇体重在该模型中无统计学显著性（p = 0.284）。
在健康妊娠中，与未治疗组相比，孕酮组胎儿NT增加。
