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本文引用的文献

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Hepatitis B virus infection.乙型肝炎病毒感染。
Nat Rev Dis Primers. 2018 Jun 7;4:18035. doi: 10.1038/nrdp.2018.35.
2
History, Diagnosis, and Management of Chronic Inflammatory Demyelinating Polyradiculoneuropathy.慢性炎症性脱髓鞘性多发性神经根神经病的历史、诊断和治疗。
Mayo Clin Proc. 2018 Jun;93(6):777-793. doi: 10.1016/j.mayocp.2018.03.026.
3
Predominant Upper Limb Chronic Demyelinating Polyneuropathy Associated with HBV Infection.与乙肝病毒感染相关的主要累及上肢的慢性脱髓鞘性多发性神经病
Maedica (Bucur). 2017 Dec;12(4):286-288.
4
Acute-onset chronic inflammatory demyelinating polyneuropathy in hantavirus and hepatitis B virus coinfection: A case report.汉坦病毒与乙型肝炎病毒合并感染所致急性起病的慢性炎症性脱髓鞘性多发性神经病：一例报告
Medicine (Baltimore). 2016 Dec;95(49):e5580. doi: 10.1097/MD.0000000000005580.
5
Dramatic Improvement of Chronic Inflammatory Demyelinating Polyneuropathy Through Tenofovir Treatment in a Patient Infected with Hepatitis B Virus.一名感染乙型肝炎病毒的患者通过替诺福韦治疗使慢性炎症性脱髓鞘性多发性神经病显著改善。
J Neuroimmune Pharmacol. 2015 Jun;10(2):191-2. doi: 10.1007/s11481-015-9607-z. Epub 2015 Apr 8.
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Extrahepatic manifestations of acute hepatitis B virus infection.急性乙型肝炎病毒感染的肝外表现
Gastroenterol Hepatol (N Y). 2013 Feb;9(2):123-6.
7
Neuromuscular disorders associated with hepatitis B virus infection.与乙型肝炎病毒感染相关的神经肌肉疾病
J Clin Neuromuscul Dis. 2011 Sep;13(1):26-37. doi: 10.1097/CND.0b013e3181df2b2b.
8
European Federation of Neurological Societies/Peripheral Nerve Society guideline on management of chronic inflammatory demyelinating polyradiculoneuropathy: report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Society - first revision.欧洲神经病学会联合会/周围神经学会关于慢性炎症性脱髓鞘性多发性神经病管理指南：欧洲神经病学会联合会和周围神经学会联合工作组的报告-第一版修订。
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9
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核苷类似物和皮质类固醇成功治疗乙型肝炎病毒肝硬化患者的慢性炎症性脱髓鞘性多发性神经病

Successful Nucleoside Analog and Corticosteroid Therapy for Chronic Inflammatory Demyelinating Polyneuropathy in a Patient With Hepatitis B Virus Liver Cirrhosis.

作者信息

Nugraha Eka Surya, Huang Ian, Supriyadi Rudi, Girawan Dolvy, Bestari Muhammad Begawan

机构信息

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Hasan Sadikin General Hospital, Universitas Padjadjaran, Bandung, Indonesia.

Department of Internal Medicine, Hasan Sadikin General Hospital, Universitas Padjadjaran, Bandung, Indonesia.

出版信息

ACG Case Rep J. 2021 Jan 13;8(1):e00519. doi: 10.14309/crj.0000000000000519. eCollection 2021 Jan.

DOI:10.14309/crj.0000000000000519
PMID:33457438
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7808564/
Abstract

Here, we describe the case of a 44-year-old man with chronic hepatitis B virus (HBV) infection, who was admitted with progressive muscle weakness and paresthesia in all extremities. He showed slight icterus. Positive HBV e-antigen test, significant HBV-deoxyribonucleic acid load, hypoalbuminemia, hyperbilirubinemia, mild ascites, and demyelinating peripheral axonal lesions in both sensory and motor nerves led to the diagnosis of Child-Pugh class B HBV cirrhosis with chronic inflammatory demyelinating polyneuropathy. Oral lamivudine, intravenous steroids, calcium, and vitamin D therapy led to a significant recovery of muscle strength within 6 weeks and a gradual return to normal after 24 weeks.

摘要

在此，我们描述了一名44岁慢性乙型肝炎病毒（HBV）感染男性的病例，该患者因四肢进行性肌无力和感觉异常入院。他有轻度黄疸。HBV e抗原检测呈阳性、HBV脱氧核糖核酸载量显著、低白蛋白血症、高胆红素血症、轻度腹水以及感觉和运动神经均出现脱髓鞘性周围轴索性病变，这些表现导致该患者被诊断为Child-Pugh B级HBV肝硬化合并慢性炎症性脱髓鞘性多发性神经病。口服拉米夫定、静脉注射类固醇、钙剂和维生素D治疗使患者在6周内肌肉力量显著恢复，并在24周后逐渐恢复正常。