Sylvén C, Borg G, Brandt R, Beermann B, Jonzon B
Karolinska Institute, Department of Medicine, Danderyds Hospital, Sweden.
Eur Heart J. 1988 Jan;9(1):87-91.
In an analysis of the psychophysical power function of chest pain induced by adenosine, this agent was repeatedly given in increasing doses into a peripheral vein to six healthy volunteers (five men) aged 23-44 years. On the first day the maximum tolerable dose was determined. On the second day seven doses of adenosine (20, 30, 40, 50, 60, 80 and 100% of the maximum dose) were given single blind in randomized order followed by another seven doses in reversed order. The heart rate was calculated from electrocardiographic recordings. Chest pain was continuously rated according to the CR-10 scale. Before the adenosine test, the perception of sourness was tested similarly with six concentrations of citric acid (1-100 mM). The psychophysical power functions were similar for the perception of sourness provoked by citric acid and chest pain provoked by adenosine, with exponents of 0.69 +/- 0.21 and 0.60 +/- 0.32, respectively. The two modalities showed the same high goodness of fit to the power function (rxy being 0.965 +/- 0.030 and 0.967 +/- 0.033, respectively). For adenosine the group mean relation was R = 1.66(S-2.36)0.6, rxy = 0.999. No signs of tolerance were observed for the chest pain provoked by adenosine. In conclusion, chest pain provoked by adenosine follows a psychophysical power function as with other sensory modalities.
在一项对腺苷诱发胸痛的心理物理功率函数的分析中，对6名年龄在23 - 44岁的健康志愿者（5名男性）经外周静脉重复给予递增剂量的该药物。第一天确定最大耐受剂量。第二天，以随机顺序单盲给予七剂腺苷（最大剂量的20%、30%、40%、50%、60%、80%和100%），随后以相反顺序再给予七剂。根据心电图记录计算心率。胸痛按照CR - 10量表持续评分。在腺苷测试前，用六种浓度的柠檬酸（1 - 100 mM）以类似方式测试酸味感知。柠檬酸诱发的酸味感知和腺苷诱发的胸痛的心理物理功率函数相似，指数分别为0.69±0.21和0.60±0.32。这两种模式对功率函数显示出相同的高度拟合优度（rxy分别为0.965±0.030和0.967±0.033）。对于腺苷，组均值关系为R = 1.66(S - 2.36)0.6，rxy = 0.999。未观察到腺苷诱发胸痛的耐受迹象。总之，腺苷诱发的胸痛与其他感觉模式一样遵循心理物理功率函数。
