Jensen Simon V, Valdetaro Lia B, Poulsen Per R, Balling Peter, Petersen Jørgen B B, Muren Ludvig P
Danish Center for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark.
Department of Physics and Astronomy, Aarhus University, Aarhus, Denmark.
Phys Imaging Radiat Oncol. 2020 Nov 20;16:134-137. doi: 10.1016/j.phro.2020.11.004. eCollection 2020 Oct.
Intrafractional motion and deformation influence proton therapy delivery for tumours in the thorax, abdomen and pelvis. This study aimed to test the dose-response of a compressively strained three-dimensional silicone-based radiochromic dosimeter during proton beam delivery. The dosimeter was read-out in its relaxed state using optical computed tomography and calibrated for the linear energy transfer, based on Monte Carlo simulations. A three-dimensional gamma analysis showed a 99.3% pass rate for 3%/3 mm and 93.9% for 2%/2 mm, for five superimposed measurements using deformation-including Monte Carlo dose calculations as reference. We conclude that the dosimeter's dose-response is unaffected by deformations.
分次内运动和形变会影响胸部、腹部和骨盆肿瘤的质子治疗。本研究旨在测试质子束照射期间压缩应变三维硅基放射变色剂量计的剂量响应。使用光学计算机断层扫描在剂量计的松弛状态下进行读数，并基于蒙特卡洛模拟对其进行线能量转移校准。三维伽马分析显示，以包含形变的蒙特卡洛剂量计算作为参考，五次叠加测量的3%/3 mm通过率为99.3%，2%/2 mm通过率为93.9%。我们得出结论，剂量计的剂量响应不受形变影响。
