贝伐单抗联合立体定向体部放疗治疗结直肠癌肝转移的灌注成像
Perfusion imaging of colorectal liver metastases treated with bevacizumab and stereotactic body radiotherapy.
作者信息
Detsky Jay S, Milot Laurent, Ko Yoo-Joung, Munoz-Schuffenegger Pablo, Chu William, Czarnota Gregory, Chung Hans T
机构信息
Department of Radiation Oncology, Odette Cancer Center, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada.
出版信息
Phys Imaging Radiat Oncol. 2018 Jan 13;5:9-12. doi: 10.1016/j.phro.2018.01.001. eCollection 2018 Jan.
Abstract
Stereotactic body radiotherapy (SBRT) and bevacizumab are used in the treatment of colorectal liver metastases. This study prospectively evaluated changes in perfusion of liver metastases in seven patients treated with both bevacizumab and SBRT. Functional imaging using dynamic contrast-enhanced CT perfusion and contrast-enhanced ultrasound were performed at baseline, after bevacizumab, and after SBRT. After bevacizumab, a significant decrease was found in permeability (-28%, p < .05) and blood volume (-47%, p < .05), while SBRT led to a significant reduction in permeability (-22%, p < .05) and blood flow (-37%, p < .05). This study demonstrates that changes in perfusion can be detected after bevacizumab and SBRT.
摘要
立体定向体部放射治疗（SBRT）和贝伐单抗用于治疗结直肠癌肝转移。本研究前瞻性评估了7例接受贝伐单抗和SBRT联合治疗的患者肝转移灶灌注的变化。在基线、使用贝伐单抗后以及使用SBRT后，采用动态对比增强CT灌注和对比增强超声进行功能成像。使用贝伐单抗后，发现通透性显著降低（-28%，p<0.05）和血容量显著降低（-47%，p<0.05），而SBRT导致通透性显著降低（-22%，p<0.05）和血流显著降低（-37%，p<0.05）。本研究表明，在使用贝伐单抗和SBRT后可检测到灌注变化。
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