Physiology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran.
Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran.
Int Urol Nephrol. 2021 Nov;53(11):2299-2310. doi: 10.1007/s11255-020-02761-y. Epub 2021 Jan 17.
Acute kidney injury (AKI) is a common syndrome associated with high morbidity and mortality, despite progress in medical care. Many studies have shown that there are sex differences and different role of sex hormones particularly estrogens in kidney injury. In this regard, the incidence and rate of progression of kidney diseases are higher in men compared with women. These observations suggest that female sex hormone may be renoprotective. Silent information regulator 2 homolog 1 (SIRT1) is a histone deacetylase, which is implicated in multiple biologic processes in several organisms. In the kidneys, SIRT1 inhibits renal cell apoptosis, inflammation, and fibrosis. Studies have reported a link between SIRT1 and estrogen. In addition, SIRT1 regulates ERα expression and inhibition of SIRT1 activity suppresses ERα expression. This effect leads to inhibition of estrogen-responsive gene expression. In this text, we review the role of SIRT1 in mediating the protective effects of estrogen in the onset and progression of AKI.
急性肾损伤（AKI）是一种常见的综合征，尽管医疗水平有所进步，但仍与高发病率和死亡率相关。许多研究表明，性别差异存在，性激素特别是雌激素在肾损伤中具有不同的作用。在这方面，与女性相比，男性的肾脏疾病发病率和进展速度更高。这些观察结果表明，女性性激素可能具有肾脏保护作用。沉默信息调节因子 2 同源物 1（SIRT1）是一种组蛋白去乙酰化酶，它参与了多种生物过程。在肾脏中，SIRT1 抑制肾细胞凋亡、炎症和纤维化。研究报告了 SIRT1 与雌激素之间的联系。此外，SIRT1 调节 ERα 的表达，抑制 SIRT1 的活性会抑制 ERα 的表达。这种作用导致抑制雌激素反应基因的表达。在本文中，我们综述了 SIRT1 在介导雌激素对 AKI 发病和进展的保护作用中的作用。
