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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Takayanagi I, Konno F, Sato Y, Uno H

Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences, Chiba, Japan.

Gen Pharmacol. 1988;19(1):117-21. doi: 10.1016/0306-3623(88)90016-x.

Pharmacological properties of a new centrally acting muscle relaxant (NC-1200) were tested in isolated muscle preparations. 2. NC-1200 acted as a Ca-blocker in the guinea pig taenia caecum. The pA2-value was 5.67. 3. In the rabbit aorta, NC-1200 competed with serotonin at serotonin receptors and also shifted the concentration response curves of histamine and norepinephrine suggesting the possibility that NC-1200 interacted with histamine and norepinephrine receptors. The pA2-value of NC-1200 against serotonin was 6.02. 4. There was no evidence that NC-1200 interacted with drug-receptors in the muscles except the rabbit aorta. 5. The present results are similar to the previous findings that the properties of serotonin, histamine and norepinephrine receptors in the rabbit aorta were different from those in other muscles.

在离体肌肉制剂中测试了一种新型中枢性肌肉松弛剂（NC - 1200）的药理特性。2. NC - 1200在豚鼠盲肠带中起钙阻滞剂的作用。pA2值为5.67。3. 在兔主动脉中，NC - 1200在血清素受体处与血清素竞争，并且还使组胺和去甲肾上腺素的浓度 - 反应曲线发生位移，这表明NC - 1200与组胺和去甲肾上腺素受体相互作用的可能性。NC - 1200对血清素的pA2值为6.02。4. 没有证据表明NC - 1200与除兔主动脉外的肌肉中的药物受体相互作用。5. 目前的结果与先前的发现相似，即兔主动脉中血清素、组胺和去甲肾上腺素受体的特性与其他肌肉中的不同。

Takayanagi I, Konno F, Sato Y, Uno H

Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences, Chiba, Japan.

Gen Pharmacol. 1988;19(1):117-21. doi: 10.1016/0306-3623(88)90016-x.

Pharmacological properties of a new centrally acting muscle relaxant (NC-1200) were tested in isolated muscle preparations. 2. NC-1200 acted as a Ca-blocker in the guinea pig taenia caecum. The pA2-value was 5.67. 3. In the rabbit aorta, NC-1200 competed with serotonin at serotonin receptors and also shifted the concentration response curves of histamine and norepinephrine suggesting the possibility that NC-1200 interacted with histamine and norepinephrine receptors. The pA2-value of NC-1200 against serotonin was 6.02. 4. There was no evidence that NC-1200 interacted with drug-receptors in the muscles except the rabbit aorta. 5. The present results are similar to the previous findings that the properties of serotonin, histamine and norepinephrine receptors in the rabbit aorta were different from those in other muscles.

在离体肌肉制剂中测试了一种新型中枢性肌肉松弛剂（NC - 1200）的药理特性。2. NC - 1200在豚鼠盲肠带中起钙阻滞剂的作用。pA2值为5.67。3. 在兔主动脉中，NC - 1200在血清素受体处与血清素竞争，并且还使组胺和去甲肾上腺素的浓度 - 反应曲线发生位移，这表明NC - 1200与组胺和去甲肾上腺素受体相互作用的可能性。NC - 1200对血清素的pA2值为6.02。4. 没有证据表明NC - 1200与除兔主动脉外的肌肉中的药物受体相互作用。5. 目前的结果与先前的发现相似，即兔主动脉中血清素、组胺和去甲肾上腺素受体的特性与其他肌肉中的不同。