从 中分离得到的新黄酮苷及其对蛋白酪氨酸磷酸酶 1B 的抑制活性。
New flavonoid glycosides from with their protein tyrosine phosphatase 1B inhibitory activity.
机构信息
Department of Pharmacy, The First People's Hospital of Yongkang, Yongkang 321300, China.
Department of Pharmacy, The People's Hospital of Jinyun, Jinyun 321400, China.
出版信息
J Asian Nat Prod Res. 2022 Jan;24(1):45-51. doi: 10.1080/10286020.2021.1873957. Epub 2021 Jan 18.
Two new flavonoid glycosides named 6-hydroxy-3-methoxy-apigenin 7---ʟ-rhamnopyranoside () and 3-hydroxyl-apigenin 8-C--ᴅ-xylopyranoside (), along with five known compounds (), were isolated from . Their structures were elucidated on the basis of spectroscopic and physicochemical analyses. All compounds were evaluated for inhibitory activity against PTP1B. Among them, compounds and showed significant inhibitory activity on PTP1B with IC values of 11.3 ± 1.7 and 8.9 ± 0.7 μM, respectively.
从 中分离得到了两个新的黄酮苷类化合物，分别命名为 6-羟基-3-甲氧基芹菜素 7-O--L-鼠李吡喃糖苷 () 和 3-羟基芹菜素 8-C--D-木吡喃糖苷 ()，同时还分离得到了另外 5 个已知化合物 ()。基于光谱和物理化学分析，确定了它们的结构。所有化合物均对 PTP1B 的抑制活性进行了评价。其中，化合物 和 对 PTP1B 表现出显著的抑制活性，IC 值分别为 11.3±1.7 和 8.9±0.7 μM。
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