Key Laboratory of Smart Drug Delivery, Ministry of Education, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, China.
Curr Drug Targets. 2021;22(8):882-895. doi: 10.2174/1389450122666210114095859.
The emergence of nanoscale drug delivery systems provides new opportunities for targeting the delivery of chemotherapeutic drugs and has achieved excellent results. In recent years, with the rise in the concept of intelligent drug delivery systems, the design and preparation of carriers have become more and more complicated, which is not conducive to clinical transformation. Researchers are gradually focused on biomimetic nanoscale drug delivery systems, trying to combine the physicochemical properties of nanoscale carriers with the natural biological functions of endogenous substances, so as to boost tumor targeting delivery. In this article, we first classify and introduce biomimetic nanoscale drug delivery systems, and then emphasize their unique biological functions. The biomimetic nanoscale drug delivery systems have the advantages of simple preparation, powerful functions, and low immunogenicity, having a good application prospect.
纳米药物递送系统的出现为化疗药物的靶向递送提供了新的机会，并取得了优异的效果。近年来，随着智能药物递送系统概念的兴起，载体的设计和制备变得越来越复杂，不利于临床转化。研究人员逐渐关注仿生纳米药物递送系统，试图将纳米载体的物理化学性质与内源性物质的天然生物学功能相结合，以促进肿瘤靶向递药。本文首先对仿生纳米药物递送系统进行分类介绍，然后重点强调其独特的生物学功能。仿生纳米药物递送系统具有制备简单、功能强大、免疫原性低等优点，具有良好的应用前景。
