Department of Pharmacy, First Affiliated Hospital of Naval Medical University (Shanghai Changhai Hospital), Shanghai, 200433, People's Republic of China.
School of Life Sciences and Biopharmaceuticals, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China.
Int J Nanomedicine. 2024 Jan 18;19:571-608. doi: 10.2147/IJN.S442877. eCollection 2024.
With the development of nanotechnology, nanoparticles (NPs) have shown broad prospects as drug delivery vehicles. However, they exhibit certain limitations, including low biocompatibility, poor physiological stability, rapid clearance from the body, and nonspecific targeting, which have hampered their clinical application. Therefore, the development of novel drug delivery systems with improved biocompatibility and high target specificity remains a major challenge. In recent years, biofilm mediated biomimetic nano-drug delivery system (BNDDS) has become a research hotspot focus in the field of life sciences. This new biomimetic platform uses bio-nanotechnology to encapsulate synthetic NPswithin biomimetic membrane, organically integrating the low immunogenicity, low toxicity, high tumor targeting, good biocompatibility of the biofilm with the adjustability and versatility of the nanocarrier, and shows promising applications in the field of precision tumor therapy. In this review, we systematically summarize the new progress in BNDDS used for optimizing drug delivery, providing a theoretical reference for optimizing drug delivery and designing safe and efficient treatment strategies to improve tumor treatment outcomes.
随着纳米技术的发展，纳米颗粒（NPs）作为药物输送载体显示出广阔的前景。然而，它们表现出某些局限性，包括低生物相容性、较差的生理稳定性、从体内迅速清除和非特异性靶向，这阻碍了它们的临床应用。因此，开发具有改善的生物相容性和高靶向特异性的新型药物输送系统仍然是一个主要挑战。近年来，生物膜介导的仿生纳米药物输送系统（BNDDS）已成为生命科学领域的研究热点。这个新的仿生平台利用生物纳米技术将合成的 NP 封装在仿生膜内，有机地整合了生物膜的低免疫原性、低毒性、高肿瘤靶向性、良好的生物相容性与纳米载体的可调节性和多功能性，并在精准肿瘤治疗领域显示出有前景的应用。在这篇综述中，我们系统地总结了用于优化药物输送的 BNDDS 的新进展，为优化药物输送和设计安全有效的治疗策略以提高肿瘤治疗效果提供了理论参考。
