Division of Neonatology, Department of Pediatrics, Connecticut Children's Medical Center and University of Connecticut School of Medicine, Farmington, CT, USA.
J Neonatal Perinatal Med. 2021;14(3):403-409. doi: 10.3233/NPM-200541.
Identify perinatal risk factors associated with SIPSTUDY DESIGN:This was a retrospective case-control study of SIP in infants born at ≤28 weeks of gestation and admitted between 1995 and 2016 at a tertiary care NICU. Infants with NEC or other GI abnormalities were excluded. Cases of SIP were matched with gestational age-matched controls with the closest birth date. Maternal, infant and birth related factors were evaluated using univariate analyses and significant factors were evaluated using multiple logistic regression.
25 cases of SIP were matched with 25 controls. No maternal factors reached statistical significance. Being one of twins increased the odds of SIP 29-fold. Birth-order or weight-discrepancy in twin had no association of SIP within twin pairs.
Twins are at significantly higher risk for SIP. The association of SIP and twin gestation was independent of previously reported risk factors of perinatal indomethacin or magnesium sulfate and merits further study.
确定与 SIP 相关的围产期风险因素。
这是一项对 1995 年至 2016 年在一家三级 NICU 住院的≤28 周龄出生的婴儿 SIP 的回顾性病例对照研究。排除 NEC 或其他胃肠道异常的婴儿。SIP 病例与具有最接近出生日期的胎龄匹配对照进行匹配。使用单变量分析评估母体、婴儿和分娩相关因素，使用多变量逻辑回归评估有意义的因素。
25 例 SIP 病例与 25 例对照相匹配。没有母体因素具有统计学意义。双胞胎之一使 SIP 的几率增加 29 倍。双胞胎中出生顺序或体重差异与双胞胎内 SIP 无关。
双胞胎 SIP 的风险显著增加。SIP 与双胞胎妊娠的关联独立于先前报道的围产期吲哚美辛或硫酸镁的风险因素，值得进一步研究。
