自发性肠穿孔与早产双胞胎婴儿有关。

Spontaneous intestinal perforation associated with premature twin infants.

机构信息

Division of Neonatology, Department of Pediatrics, Connecticut Children's Medical Center and University of Connecticut School of Medicine, Farmington, CT, USA.

出版信息

J Neonatal Perinatal Med. 2021;14(3):403-409. doi: 10.3233/NPM-200541.

DOI:10.3233/NPM-200541

PMID:33459668

Abstract

OBJECTIVE

Identify perinatal risk factors associated with SIPSTUDY DESIGN:This was a retrospective case-control study of SIP in infants born at ≤28 weeks of gestation and admitted between 1995 and 2016 at a tertiary care NICU. Infants with NEC or other GI abnormalities were excluded. Cases of SIP were matched with gestational age-matched controls with the closest birth date. Maternal, infant and birth related factors were evaluated using univariate analyses and significant factors were evaluated using multiple logistic regression.

RESULT

25 cases of SIP were matched with 25 controls. No maternal factors reached statistical significance. Being one of twins increased the odds of SIP 29-fold. Birth-order or weight-discrepancy in twin had no association of SIP within twin pairs.

CONCLUSION

Twins are at significantly higher risk for SIP. The association of SIP and twin gestation was independent of previously reported risk factors of perinatal indomethacin or magnesium sulfate and merits further study.

摘要