Department of Environmental Health and Occupational Medicine, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, P.R. China.
Department of Occupational Hazard Assessment, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, P.R. China.
J Alzheimers Dis. 2021;79(4):1409-1427. doi: 10.3233/JAD-201037.
Degenerative dementia, of which Alzheimer's disease is the most common form, is characterized by the gradual deterioration of cognitive function. The events that trigger and promote degenerative dementia are not clear, and treatment options are limited. Experimental and epidemiological studies have revealed chronic noise exposure (CNE) as a potential risk factor for cognitive impairment and degenerative dementia. Experimental studies have indicated that long-term exposure to noise might accelerate cognitive dysfunction, amyloid-β deposition, and tau hyperphosphorylation in different brain regions such as the hippocampus and cortex. Epidemiological studies are increasingly examining the possible association between external noise exposure and dementia. In this review, we sought to construct a comprehensive summary of the relationship between CNE, cognitive dysfunction, and degenerative dementia. We also present the limitations of existing evidence as a guide regarding important prospects for future research.
退行性痴呆，以阿尔茨海默病最为常见，其特征是认知功能的逐渐恶化。引发和促进退行性痴呆的事件并不清楚，治疗选择有限。实验和流行病学研究表明，慢性噪声暴露（CNE）是认知障碍和退行性痴呆的潜在危险因素。实验研究表明，长期暴露于噪声可能会加速不同脑区（如海马体和皮质）的认知功能障碍、β淀粉样蛋白沉积和 tau 过度磷酸化。流行病学研究越来越关注外部噪声暴露与痴呆之间的可能关联。在这篇综述中，我们试图综合总结 CNE、认知功能障碍和退行性痴呆之间的关系。我们还提出了现有证据的局限性，为未来研究的重要前景提供了指导。
