Cho Inja, Kim Jeongmin, Jung Seungho, Kim So Yeon, Kim Eun Jung, Choo Sungji, Kam Eun Hee, Koo Bon-Nyeo
Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
Healthcare (Basel). 2023 Jul 19;11(14):2067. doi: 10.3390/healthcare11142067.
The aim of this study was to investigate the impact of noise exposure in an intensive care unit (ICU) environment on the development of postoperative delirium in a mouse model that mimics the ICU environment. Additionally, we aimed to identify the underlying mechanisms contributing to delirium and provide evidence for reducing the risk of delirium. In this study, to mimic an ICU environment, lipopolysaccharide (LPS)-injected sepsis mouse models were exposed to a 75 dB noise condition. Furthermore, we assessed neurobehavioral function and observed the level of neuroinflammatory response and blood-brain barrier (BBB) integrity in the hippocampal region. The LPS-injected sepsis mouse model exposed to noise exhibited increased anxiety-like behavior and cognitive impairment. Moreover, severe neuroinflammation and BBB disruption were detected in the hippocampal region. This study provides insights suggesting that persistent noise exposure under systemic inflammatory conditions may cause cognitive dysfunction and anxiety- like behavior via the mediation of BBB disruption and neuroinflammation. As a result, we suggest that the detailed regulation of noise exposure may be required to prevent the development of postoperative delirium.
本研究的目的是在模拟重症监护病房（ICU）环境的小鼠模型中，调查ICU环境中的噪声暴露对术后谵妄发展的影响。此外，我们旨在确定导致谵妄的潜在机制，并为降低谵妄风险提供证据。在本研究中，为了模拟ICU环境，将注射脂多糖（LPS）的脓毒症小鼠模型暴露于75分贝的噪声环境中。此外，我们评估了神经行为功能，并观察了海马区的神经炎症反应水平和血脑屏障（BBB）完整性。暴露于噪声中的注射LPS的脓毒症小鼠模型表现出焦虑样行为增加和认知障碍。此外，在海马区检测到严重的神经炎症和血脑屏障破坏。本研究提供的见解表明，全身炎症条件下的持续噪声暴露可能通过血脑屏障破坏和神经炎症的介导导致认知功能障碍和焦虑样行为。因此，我们建议可能需要对噪声暴露进行详细调节，以预防术后谵妄的发生。
