Sichuan University-University of Oxford Huaxi Joint Centre for Gastrointestinal Cancer, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
Food Funct. 2021 Feb 15;12(3):990-1007. doi: 10.1039/d0fo03001e.
Pulmonary fibrosis is an incurable end-stage lung disease and remains a global public health problem. Although there have been some breakthroughs in understanding the pathogenesis of pulmonary fibrosis, effective intervention methods are still limited. Natural products have the advantages of multiple biological activities and high levels of safety, which are important factors for preventing and treating pulmonary fibrosis. In this review, we summarized the mechanisms and health benefits of natural products against pulmonary fibrosis. These natural products target oxidative stress, inflammatory injury, epithelial-mesenchymal transition (EMT), fibroblast activation, extracellular matrix accumulation and metabolic regulation, and the mechanisms involve the NF-κB, TGF-β1/Smad, PI3K/Akt, p38 MAPK, Nrf2-Nox4, and AMPK signaling pathways. We hope to provide new ideas for pulmonary fibrosis prevention and treatment strategies.
肺纤维化是一种不可治愈的终末期肺部疾病，仍然是一个全球性的公共卫生问题。尽管人们在理解肺纤维化发病机制方面已经取得了一些突破，但有效的干预方法仍然有限。天然产物具有多种生物活性和高水平安全性的优势，是预防和治疗肺纤维化的重要因素。在这篇综述中，我们总结了天然产物防治肺纤维化的作用机制和健康益处。这些天然产物针对氧化应激、炎症损伤、上皮-间充质转化（EMT）、成纤维细胞激活、细胞外基质积累和代谢调节，其作用机制涉及 NF-κB、TGF-β1/Smad、PI3K/Akt、p38 MAPK、Nrf2-Nox4 和 AMPK 信号通路。我们希望为肺纤维化的防治策略提供新的思路。
