Department of Ophthalmology, University of Health Sciences, Sisli Hamidiye Etfal Training and Research Hospital, Halaskargazi Avenue, Etfal Street 34371, Şişli, Istanbul, Turkey.
Int Ophthalmol. 2021 Apr;41(4):1337-1345. doi: 10.1007/s10792-021-01700-9. Epub 2021 Jan 18.
To evaluate the retinal nerve fiber layer (RNFL) and peripapillary vascular density (VD) changes in the pediatric group with optic disk drusen (ODD).
Sixty eyes of 30 patients with buried ODD referred by the pediatric or neurology physicians to ophthalmology clinic with a preliminary diagnosis of papillary edema were included in this retrospective study. Sixty eyes of 30 healthy children were included as the control group. Thickness of RNFL (micrometer) and VD percentages (%) of the superior, inferior, nasal, and temporal quadrants of the peripapillary region of all cases were evaluated with optical coherence tomography angiography (OCT-A) device.
The study and control groups were homogeneous in terms of age and gender. VD values were significantly lower in the study group for all four quadrants, when compared to controls (p < 0.001, p < 0.001, p = 0.003, and p < 0.001, for inferior, superior, nasal, and temporal quadrants, respectively. For RFNL thickness measurements, a significant difference between groups was only evident for the nasal quadrant, where the study group had significantly higher nasal RFNL thickness (p = 0.001).
This study detected decreases in peripapillary VD values in all quadrants and peripapillary RNFL thickening in nasal quadrant in pediatric cases with buried drusen compared to healthy controls. Further studies are necessary to reveal the effects of drusen pathogenesis on optic nerve head perfusion and to understand the underlying mechanisms of related complications.
评估具有视盘玻璃膜疣（ODD）的儿科人群的视网膜神经纤维层（RNFL）和视盘周围血管密度（VD）变化。
本回顾性研究纳入了 30 名由儿科或神经科医生转诊至眼科诊所、初步诊断为乳头水肿的埋藏性 ODD 患者的 60 只眼，这些患者包括在研究中。同时纳入了 30 名健康儿童的 60 只眼作为对照组。使用光学相干断层扫描血管造影（OCT-A）设备评估所有病例视盘周围区域的 RNFL 厚度（微米）和 VD 百分比（%）。
研究组和对照组在年龄和性别方面具有同质性。与对照组相比，研究组所有四个象限的 VD 值均显著降低（p<0.001、p<0.001、p=0.003 和 p<0.001，分别为下方、上方、鼻侧和颞侧象限）。对于 RFNL 厚度测量，仅在鼻侧象限两组之间存在显著差异，研究组的鼻侧 RFNL 厚度明显更高（p=0.001）。
与健康对照组相比，本研究在埋藏性玻璃膜疣的儿科病例中发现了所有象限的视盘周围 VD 值降低和鼻侧象限的视盘周围 RNFL 增厚。需要进一步研究来揭示玻璃膜疣发病机制对视神经头灌注的影响，并了解相关并发症的潜在机制。
