Wang X Q, Gan L Y, Ma J, Zhong Y
Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
Zhonghua Yan Ke Za Zhi. 2022 Mar 11;58(3):200-204. doi: 10.3760/cma.j.cn112142-20210328-00144.
To investigate the changes of the microstructure and vascular density in the superficial retinal layer of buried optic disc drusen (ODD) patients. Retrospective case-control study. A total of 36 ODD eyes (20 patients) and 26 normal control eyes were recruited in Beijing Union Medical College Hospital from January 2018 to July 2020. Measurement of best corrected visual acuity (BCVA), intraocular pressure, slit lamp, fundus examination and visual field examination were performed. The images and data of spectral domain-optical coherence tomography (SD-OCT) and optical coherence tomography angiography (OCTA) were analyzed and summarized. The differences of nasal retinal nerve fiber layer (RNFL), ganglion cell complex (GCC) thickness and macular superficial vascular density (VD) between ODD patients and normal controls were compared by independent sample -test or Mann Whitney test (the right eye was selected in bilateral ODD patients). The 20 ODD patients and 26 normal controls were all female. There was no significant difference in age between the two groups (>0.05). The BCVA and visual field examination was normal in all ODD patients. The SD-OCT examination showed an oval low signal shadow under the nasal outer nuclear layer of the optic disc, or local accumulation like a medium signal shadow with a clear boundary, and a high signal capsule in ODD patients. The RNFL in the upper nasal side of the ODD group was significantly different from the normal control group [(102.6±19.1) μm . (119.0±13.8) μm; =-2.81; <0.01]. Compared with normal control group [101.0 (100.0, 102.0) μm], the average GCC thickness in the ODD group [97.0 (89.3, 99.8) μm] was significantly different (=48.50; <0.01). The OCTA en-face scan showed that the vascular network in the macular area of the affected eyes was sparser than that of the control eyes. There was significant difference in superficial macular VD beteeen the ODD group (48.5%±2.8%) and the control group (51.0%±2.3%) (=-2.63; <0.05). There is thinning in the RNFL upper nasal side and GCC layer of the macular region in buried ODD patients, and the superficial VD of the macular region in buried ODD patients is lower than that in the normal controls.
探讨埋藏性视盘玻璃疣（ODD）患者视网膜浅层的微观结构和血管密度变化。回顾性病例对照研究。2018年1月至2020年7月，北京协和医院共纳入36只ODD眼（20例患者）和26只正常对照眼。进行最佳矫正视力（BCVA）、眼压、裂隙灯、眼底检查和视野检查。对频域光学相干断层扫描（SD - OCT）和光学相干断层扫描血管造影（OCTA）的图像和数据进行分析总结。采用独立样本t检验或Mann - Whitney检验比较ODD患者与正常对照者鼻侧视网膜神经纤维层（RNFL）、神经节细胞复合体（GCC）厚度及黄斑区浅层血管密度（VD）的差异（双侧ODD患者选取右眼）。20例ODD患者和26例正常对照者均为女性。两组年龄差异无统计学意义（>0.05）。所有ODD患者的BCVA和视野检查均正常。SD - OCT检查显示ODD患者视盘鼻侧外核层下方呈椭圆形低信号影，或局部呈中等信号影积聚，边界清晰，有高信号包膜。ODD组鼻上侧RNFL与正常对照组有显著差异[（102.6±19.1）μm 对（119.0±13.8）μm；t = - 2.81；P <0.01]。与正常对照组[101.0（100.0，102.0）μm]相比，ODD组平均GCC厚度[97.0（89.3，99.8）μm]有显著差异（Z = 48.50；P <0.01）。OCTA表面扫描显示患眼黄斑区血管网络比对照眼稀疏。ODD组（48.5%±2.8%）与对照组（51.0%±2.3%）黄斑区浅层VD有显著差异（t = - 2.63；P <0.05）。埋藏性ODD患者黄斑区鼻上侧RNFL和GCC层变薄，埋藏性ODD患者黄斑区浅层VD低于正常对照组。
