Robey S S, Olson J L, Brem H, Epstein J I
Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Hum Pathol. 1988 Mar;19(3):365-7. doi: 10.1016/s0046-8177(88)80533-1.
A case of a neuroblastoma occurring in the cerebellum of a 73-year-old man is reported. The patient presented with progressive truncal ataxia and was found to have an enhancing tumor mass in the cerebellar vermis. By light microscopy, the tumor was a small cell neoplasm and was similar to medulloblastoma, with areas showing structures suggestive of Homer-Wright pseudorosettes. By electron microscopy and immunoperoxidase techniques, however, the tumor showed convincing evidence of neuronal differentiation. The absence of previous reports of this tumor in the posterior fossa of adults suggests that immunoperoxidase techniques and/or electron microscopy of such small cell tumors may be required for accurate diagnosis.
报告了一例发生在一名73岁男性小脑的神经母细胞瘤病例。患者表现为进行性躯干共济失调，在小脑蚓部发现有强化的肿瘤块。光镜下，肿瘤为小细胞肿瘤，与髓母细胞瘤相似，部分区域可见提示霍纳-赖特假菊形团的结构。然而，通过电子显微镜和免疫过氧化物酶技术，肿瘤显示出令人信服的神经分化证据。此前无成人后颅窝发生该肿瘤的报道，这表明对于此类小细胞肿瘤，可能需要采用免疫过氧化物酶技术和/或电子显微镜进行准确诊断。
