Department of Emergency, LongHua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
Dalian Key Laboratory of Metabolic Target Characterization and Traditional Chinese Medicine Intervention, College of Pharmacy, College of Integrative Medicine, Dalian Medical University, Dalian, 116044, China.
J Ethnopharmacol. 2021 Apr 24;270:113840. doi: 10.1016/j.jep.2021.113840. Epub 2021 Jan 15.
The genus Sargentodoxa comprises only one species, Sargentodoxa cuneata (Oliv.) Rehd et al., widely distributed in the subtropical zone of China. The plant is extensively used in traditional medicine for treating arthritis, joint pains, amenorrhea, acute appendicitis and inflammatory intestinal obstruction. Pharmacological studies show anti-inflammatory, antioxidant, antitumor, antimicrobial, and anti-sepsis activities.
This review aims to summarize the information about distribution, traditional uses, chemical constituents and pharmacological activities of S. cuneata, as an attempt to provide a scientific basis for its traditional uses and to support its application and development for new drug development.
Scientific information of S. cuneata was retrieved from the online bibliographic databases, including Web of Science, Google Scholar, PubMed, Springer Link, the Wiley online library, SciFinder, Baidu Scholar, China national knowledge infrastructure (CNKI) and WANFANG DATA (up to March 2020). We also search doctoral dissertations, master dissertations conference papers and published books. The keywords were used: "Sargentodoxa", "Da Xue Teng", "Hong Teng", "Xue Teng", "secondary metabolites", "chemical components", "biological activity", "pharmacology", "traditional uses".
S. cuneata is utilized as valuable herbal medicines to treat various diseases in China. Over 110 chemical constituents have been isolated and identified from the stem of S. cuneata, including phenolic acids, phenolic glycosides, lignans, flavones, triterpenoids and other compounds. The extract and compounds of S. cuneata have a wide spectrum of pharmacological activities, including antitumor, anti-inflammatory, antioxidant, antimicrobial, anti-sepsis and anti-arthritis effects, as well as protective activity against cerebrovascular diseases.
S. cuneata has a rich legacy for the treatment of many diseases, especially arthritis and sepsis, which is reinforced by current investigations. However, the present studies about bioactive chemical constituents and detail pharmacological mechanisms of S. cuneata were insufficient. Further studies should focus on these aspects in relation to its clinical applications. This review has systematically summarized the traditional uses, phytochemical constituents and pharmacological effects of S. cuneata, providing references for the therapeutic potential of new drug development.
该属包含一个种，即中国南方广泛分布的长瓣金莲花（Oliv.）Rehd et al.。该植物在传统医学中被广泛用于治疗关节炎、关节疼痛、闭经、急性阑尾炎和炎性肠梗阻。药理研究表明具有抗炎、抗氧化、抗肿瘤、抗菌和抗败血症作用。
本综述旨在总结长瓣金莲花的分布、传统用途、化学成分和药理活性信息，试图为其传统用途提供科学依据，并支持其在新药开发中的应用和发展。
从在线文献数据库，包括 Web of Science、Google Scholar、PubMed、Springer Link、Wiley Online Library、SciFinder、百度学术、中国国家知识基础设施（CNKI）和万方数据（截至 2020 年 3 月）检索长瓣金莲花的科学信息。我们还搜索了博士论文、硕士论文、会议论文和出版书籍。关键词使用：“长瓣金莲花”、“大血藤”、“红藤”、“血藤”、“次生代谢物”、“化学成分”、“生物活性”、“药理学”、“传统用途”。
长瓣金莲花在中国被用作有价值的草药，用于治疗各种疾病。从长瓣金莲花的茎中分离鉴定出 110 多种化学成分，包括酚酸、酚糖苷、木脂素、黄酮类、三萜类化合物等。长瓣金莲花的提取物和化合物具有广泛的药理活性，包括抗肿瘤、抗炎、抗氧化、抗菌、抗败血症和抗关节炎作用，以及对脑血管疾病的保护作用。
长瓣金莲花在治疗许多疾病方面有着丰富的传统应用，特别是关节炎和败血症，这也得到了当前研究的支持。然而，目前关于长瓣金莲花生物活性化学成分和详细药理机制的研究还不够充分。未来的研究应集中在这些方面，以促进其临床应用。本综述系统总结了长瓣金莲花的传统用途、植物化学成分和药理作用，为新药开发的治疗潜力提供了参考。
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