Ministry of Health, Ankara City Hospital, Bilkent, Ankara, Turkey.
Hacettepe University, Faculty of Medicine, Department of Pediatrics, Sıhhiye, Ankara, Turkey.
Environ Toxicol Pharmacol. 2021 Apr;83:103585. doi: 10.1016/j.etap.2021.103585. Epub 2021 Jan 15.
We aim to evaluate urinary total BPA (tBPA) levels and association with medical devices used on patients in pediatric intensive care units. This cross-sectional descriptive study included 117 critically ill children. Urinary tBPA levels were determined using high-performance liquid chromatography. General estimating equations with repeated measures analyzed the effect of interventions and devices on urinary BPA levels. A total of 292 urine samples taken from 117 child intensive care patients were studied. When age, sex, and body mass index-for age z-scores were controlled, cases having endotracheal intubation showed higher urinary tBPA levels (p = 0.003) and hemodialyzed patients had considerably higher urinary tBPA levels (p = 0.004). When confounding factors were controlled, cases using both multiple iv treatment and more than four medical devices showed higher urinary tBPA levels than their counterparts (p = 0.007 and p = 0.028, respectively). The use of certain medical devices and interventions could increase BPA exposure in pediatric intensive care patients.
我们旨在评估儿科重症监护病房患者使用的医疗设备与尿总双酚 A（tBPA）水平的关联。这是一项横断面描述性研究，纳入了 117 名危重症患儿。采用高效液相色谱法测定尿 tBPA 水平。采用重复测量的一般估计方程分析了干预措施和设备对尿 BPA 水平的影响。对 117 名重症监护患儿的 292 份尿液样本进行了研究。当控制年龄、性别和体重指数年龄 z 评分后，行气管插管的病例尿 tBPA 水平更高（p=0.003），行血液透析的病例尿 tBPA 水平显著更高（p=0.004）。当控制混杂因素后，使用多种静脉治疗和 4 种以上医疗设备的病例尿 tBPA 水平均高于对照组（p=0.007 和 p=0.028）。某些医疗设备和干预措施的使用可能会增加儿科重症监护患者的 BPA 暴露。
