Suppr超能文献

尿液中 BPA 水平与儿科重症监护病房患者医疗设备的关系。

The association between urinary BPA levels and medical equipment among pediatric intensive care patients.

机构信息

Ministry of Health, Ankara City Hospital, Bilkent, Ankara, Turkey.

Hacettepe University, Faculty of Medicine, Department of Pediatrics, Sıhhiye, Ankara, Turkey.

出版信息

Environ Toxicol Pharmacol. 2021 Apr;83:103585. doi: 10.1016/j.etap.2021.103585. Epub 2021 Jan 15.

Abstract

We aim to evaluate urinary total BPA (tBPA) levels and association with medical devices used on patients in pediatric intensive care units. This cross-sectional descriptive study included 117 critically ill children. Urinary tBPA levels were determined using high-performance liquid chromatography. General estimating equations with repeated measures analyzed the effect of interventions and devices on urinary BPA levels. A total of 292 urine samples taken from 117 child intensive care patients were studied. When age, sex, and body mass index-for age z-scores were controlled, cases having endotracheal intubation showed higher urinary tBPA levels (p = 0.003) and hemodialyzed patients had considerably higher urinary tBPA levels (p = 0.004). When confounding factors were controlled, cases using both multiple iv treatment and more than four medical devices showed higher urinary tBPA levels than their counterparts (p = 0.007 and p = 0.028, respectively). The use of certain medical devices and interventions could increase BPA exposure in pediatric intensive care patients.

摘要

我们旨在评估儿科重症监护病房患者使用的医疗设备与尿总双酚 A(tBPA)水平的关联。这是一项横断面描述性研究,纳入了 117 名危重症患儿。采用高效液相色谱法测定尿 tBPA 水平。采用重复测量的一般估计方程分析了干预措施和设备对尿 BPA 水平的影响。对 117 名重症监护患儿的 292 份尿液样本进行了研究。当控制年龄、性别和体重指数年龄 z 评分后,行气管插管的病例尿 tBPA 水平更高(p=0.003),行血液透析的病例尿 tBPA 水平显著更高(p=0.004)。当控制混杂因素后,使用多种静脉治疗和 4 种以上医疗设备的病例尿 tBPA 水平均高于对照组(p=0.007 和 p=0.028)。某些医疗设备和干预措施的使用可能会增加儿科重症监护患者的 BPA 暴露。

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验