MM 42842，由椰毒假单胞菌产生的单环β-内酰胺家族的一个新成员。I. 产生菌的鉴定。

MM 42842, a new member of the monobactam family produced by Pseudomonas cocovenenans. I. Identification of the producing organism.

作者信息

Gwynn M N, Box S J, Brown A G, Gilpin M L

机构信息

Beecham Pharmaceuticals, Chemotherapeutic Research Centre, Betchworth, Surrey, UK.

出版信息

J Antibiot (Tokyo). 1988 Jan;41(1):1-6. doi: 10.7164/antibiotics.41.1.

DOI:10.7164/antibiotics.41.1

PMID:3346181

Abstract

A bacterial soil isolate designated 326-32B produces a new member of the monobactam series of antibiotics, MM 42842, and the bulgecins. Identification studies show isolate 326-32B to be a strain of Pseudomonas cocoveneans which is a species previously noted for the production of toxoflavin. A description of P. cocovenenans does not appear to have been previously published and the identify of strain 326-32B was established by means of a direct comparison with the deposited organism P. cocovenenans NCIB 9450. The properties of strain 326-32B, and P. cocovenenans NCIB 9450 were compared with those of the monobactam and bulgecin producing organisms Pseudomonas acidophila ATCC 31363 and Pseudomonas mesoacidophila ATCC 31433. The four organisms were found to share certain properties, including the ability to grow at pH 4.0.

摘要

一种名为326 - 32B的土壤细菌分离株可产生单环β - 内酰胺类抗生素系列的一个新成员MM 42842以及膨菌素。鉴定研究表明，分离株326 - 32B是椰毒假单胞菌的一个菌株，该物种此前因产生毒黄素而闻名。此前似乎尚未发表过关于椰毒假单胞菌的描述，326 - 32B菌株的鉴定是通过与保藏菌株椰毒假单胞菌NCIB 9450直接比较来确定的。将326 - 32B菌株和椰毒假单胞菌NCIB 9450的特性与产生单环β - 内酰胺类抗生素和膨菌素的嗜酸假单胞菌ATCC 31363及嗜中酸假单胞菌ATCC 31433的特性进行了比较。发现这四种生物具有某些共同特性，包括在pH 4.0条件下生长的能力。