一药打尽：磺胺噻唑的故事。

One Ring to Fight Them All: The Sulfazecin Story.

机构信息

Junior Research Group Synthetic Microbiology, Friedrich Schiller University at the Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute, Beutenbergstr.11a, 07745 Jena, Germany.

出版信息

Cell Chem Biol. 2017 Jan 19;24(1):1-2. doi: 10.1016/j.chembiol.2017.01.001.

DOI:10.1016/j.chembiol.2017.01.001

PMID:28107651

Abstract

In this issue of Cell Chemical Biology, Li et al. (2017) report on the biosynthesis of the monobactam sulfazecin by Pseudomonas acidophila and hypothesize a novel mechanism of β-lactam ring formation. As monobactam antibiotics are unaffected by some emerging resistance mechanisms (particularly metallo-β-lactamases), this discovery opens prospects to engineer β-lactam antibiotics against multi-drug resistant pathogens.

摘要

在本期《细胞化学生物学》中，Li 等人（2017 年）报道了嗜酸假单胞菌合成单环β-内酰胺类抗生素磺齐菌素的生物合成途径，并提出了β-内酰胺环形成的新机制。由于单环β-内酰胺类抗生素不受一些新兴耐药机制（特别是金属β-内酰胺酶）的影响，这一发现为设计针对多药耐药病原体的β-内酰胺类抗生素开辟了前景。