Division of Endocrinology and Metabolism, Department of Internal Medicine, Chonnam National University Medical School, 8 Hak-Dong, Dong-Gu, Gwangju 501-757, Republic of Korea.
Division of Endocrinology and Metabolism, Department of Internal Medicine, Chonnam National University Medical School, 8 Hak-Dong, Dong-Gu, Gwangju 501-757, Republic of Korea.
J Diabetes Complications. 2021 Apr;35(4):107849. doi: 10.1016/j.jdiacomp.2021.107849. Epub 2021 Jan 7.
To assess the relationship between growth differentiation factor-15 (GDF-15) levels and estimated glomerular filtration rate (eGFR) in type 2 diabetes mellitus (DM) patients with and without albuminuria.
We examined 324 patients with type 2 DM in a cross-sectional study. eGFR was determined using equations from creatinine (eGFR) and the combination of creatinine and cystatin C (eGFR). The patients were classified into two groups based on urinary albumin: creatinine ratio (ACR): the normoalbuminuria group (urinary ACR < 30 mg/g) and the albuminuria group (urinary ACR ≥ 30 mg/g).
In individuals both with and without albuminuria, higher GDF-15 levels were associated with lower eGFR and eGFR. Plasma GDF-15 levels were inversely correlated with eGFR in individuals both with and without albuminuria (γ = -0.624, p < 0.001 and γ = -0.509, p < 0.001, respectively). A multiple regression analysis showed that GDF-15 levels were significantly associated with eGFR after adjusting for age, sex and other confounders, including urinary ACR as a continuous or categorical variable (β = -0.309, p < 0.001 and β = -0.318, p < 0.001, respectively). Similarly, these results were replicated when eGFR was considered instead of eGFR in correlation and regression analyses.
GDF-15 levels were inversely associated with eGFR in patients with type 2 DM. This relationship was independent of albuminuria status.
评估 2 型糖尿病（DM）伴或不伴蛋白尿患者生长分化因子 15（GDF-15）水平与估计肾小球滤过率（eGFR）之间的关系。
我们在一项横断面研究中检查了 324 例 2 型 DM 患者。使用肌酐（eGFR）和肌酐与胱抑素 C 联合（eGFR）方程确定 eGFR。根据尿白蛋白：肌酐比（ACR）将患者分为两组：正常白蛋白尿组（尿 ACR<30mg/g）和白蛋白尿组（尿 ACR≥30mg/g）。
在有或没有白蛋白尿的个体中，较高的 GDF-15 水平与较低的 eGFR 和 eGFR 相关。在有或没有白蛋白尿的个体中，血浆 GDF-15 水平与 eGFR 呈负相关（γ= -0.624，p<0.001 和 γ= -0.509，p<0.001，分别）。多元回归分析表明，在调整年龄、性别和其他混杂因素后，包括尿 ACR 作为连续或分类变量，GDF-15 水平与 eGFR 显著相关（β= -0.309，p<0.001 和 β= -0.318，p<0.001，分别）。同样，在相关和回归分析中，当考虑 eGFR 而不是 eGFR 时，也得到了类似的结果。
2 型 DM 患者的 GDF-15 水平与 eGFR 呈负相关。这种关系独立于白蛋白尿状态。
