电抽搐治疗后发现遗传性拟胆碱酯酶缺乏症。
Hereditary pseudocholinesterase deficiency discovery after electroconvulsive therapy.
机构信息
Department of Psychiatry, Cooper Medical School of Rowan University, Cooper University Health Care, Camden, New Jersey, USA.
Department of Anesthesiology, Cooper Medical School of Rowan University, Cooper University Health Care, Camden, New Jersey, USA
出版信息
BMJ Case Rep. 2021 Jan 18;14(1):e239206. doi: 10.1136/bcr-2020-239206.
Inherited pseudocholinesterase deficiency refers to an uncommon defect in the butyrylcholinesterase enzyme which can result in prolonged muscle paralysis due to delayed breakdown of choline ester paralytic anaesthetic agents. We describe a 25-year-old woman receiving electroconvulsive therapy (ECT) for treatment of depression in whom motor function did not recover adequately after administration of succinylcholine. Investigated post-ECT, she was found to have severe pseudocholinesterase deficiency. Implications of pseudocholinesterase deficiency for ECT treatment and anaesthetic strategies are discussed.
遗传性拟胆碱酯酶缺乏症是一种罕见的丁酰胆碱酯酶缺陷，可导致由于胆碱酯酶麻痹性麻醉剂分解延迟而导致肌肉瘫痪时间延长。我们描述了一位 25 岁女性，因抑郁症接受电休克治疗（ECT），在给予琥珀酰胆碱后运动功能未充分恢复。ECT 后检查发现她患有严重的拟胆碱酯酶缺乏症。讨论了拟胆碱酯酶缺乏症对 ECT 治疗和麻醉策略的影响。
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