Department of Nutrition and Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, the Netherlands.
Department of Radiology and Nuclear Medicine, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, Maastricht, the Netherlands.
Nat Metab. 2021 Jan;3(1):107-117. doi: 10.1038/s42255-020-00332-0. Epub 2021 Jan 18.
Creatine availability in adipose tissue has been shown to have profound effects on thermogenesis and energy balance in mice. However, whether dietary creatine supplementation affects brown adipose tissue (BAT) activation in humans is unclear. In the present study, we report the results of a double-blind, randomized, placebo-controlled, cross-over trial (NCT04086381) in which 14 young, healthy, vegetarian adults, who are characterized by low creatine levels, received 20 g of creatine monohydrate per day or placebo. Participants were eligible if they met the following criteria: male or female, white, aged 18-30 years, consuming a vegetarian diet (≥6 months) and body mass index 20-25 kg m. BAT activation after acute cold exposure was determined by calculating standard uptake values (SUVs) acquired by [F]fluorodeoxyglucose positron emission tomography-magnetic resonance imaging. BAT volume (-31.32 (19.32) SUV (95% confidence interval (CI) -73.06, 10.42; P = 0.129)), SUV (-0.34 (0.29) SUV (95% CI -0.97, 0.28; P = 0.254)) and SUV (-2.49 (2.64) SUV (95% CI -8.20, 3.21; P = 0.362)) following acute cold exposure were similar between placebo and creatine supplementation. No side effects of creatine supplementation were reported; one participant experienced bowel complaints during placebo, which resolved without intervention. Our data show that creatine monohydrate supplementation in young, healthy, lean, vegetarian adults does not enhance BAT activation after acute cold exposure.
脂肪组织中肌酸的含量对小鼠的产热和能量平衡有深远的影响。然而，饮食中肌酸补充是否会影响人体棕色脂肪组织（BAT）的激活尚不清楚。在本研究中，我们报告了一项双盲、随机、安慰剂对照、交叉试验（NCT04086381）的结果，该试验纳入了 14 名年轻、健康、素食的成年人，他们的肌酸水平较低，每天接受 20g 肌酸一水合物或安慰剂。参与者符合以下标准：男性或女性，白种人，年龄 18-30 岁，素食（≥6 个月），体重指数 20-25kg/m²。急性冷暴露后 BAT 的激活通过计算 [F]氟脱氧葡萄糖正电子发射断层扫描-磁共振成像获得的标准摄取值（SUVs）来确定。BAT 体积（-31.32（19.32）SUV（95%置信区间（CI）-73.06，10.42；P=0.129））、SUV（-0.34（0.29）SUV（95% CI-0.97，0.28；P=0.254））和 SUV（-2.49（2.64）SUV（95% CI-8.20，3.21；P=0.362））在急性冷暴露后在安慰剂和肌酸补充之间无差异。没有报告肌酸补充的副作用；一名参与者在接受安慰剂期间出现肠道投诉，但无需干预即可解决。我们的数据表明，在年轻、健康、瘦的素食成年人中补充肌酸一水合物不会增强急性冷暴露后 BAT 的激活。
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