饮食因素与年轻成年人棕色脂肪组织体积/F-FDG 摄取量的相关性研究。

Association between dietary factors and brown adipose tissue volume/F-FDG uptake in young adults.

机构信息

PROmoting FITness and Health through Physical Activity Research Group (PROFITH), Sport and Health University Research Institute (iMUDS), University of Granada, 18007, Granada, Spain; Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, 18011, Granada, Spain; EFFECTS 262 Research Group, Department of Medical Physiology, School of Medicine, University of Granada, 18071, Granada, Spain.

出版信息

Clin Nutr. 2021 Apr;40(4):1997-2008. doi: 10.1016/j.clnu.2020.09.020. Epub 2020 Sep 19.

DOI:10.1016/j.clnu.2020.09.020

PMID:32994069

Abstract

OBJECTIVE

To study the association between usual dietary factors (dietary energy density, nutrient intake, food group consumption, and dietary pattern) and brown adipose tissue (BAT) volume/F-fluorodeoxyglucose (F-FDG) uptake after personalized cold exposure in young healthy adults.

METHODS

A total of 122 young adults (n = 82 women; 22.0 ± 2.1 years old; 24.8 ± 4.8 kg/m) took part in this cross-sectional study. Dietary factors were measured via a food frequency questionnaire and three non-consecutive 24 h recalls. Dietary energy density (foods and caloric beverages included) and macronutrient intakes were subsequently estimated using EvalFINUT® software, food group consumption was estimated from the food frequency questionnaire, and different dietary patterns and quality indices were determined according to the reference methods. BAT volume, BAT F-FDG uptake, and skeletal muscle F-FDG uptake were assessed by static F-FDG positron-emission tomography and computed tomography (PET-CT) scans after a 2 h personalized exposure to cold.

RESULTS

A direct association was detected between dietary energy density and BAT Standardized Uptake Value (SUV)mean (β = 0.215; R = 0.044; P = 0.022), and between ethanol consumption and BAT volume (β = 0.215; R = 0.044; P = 0.022). The a priori Mediterranean dietary pattern was inversely associated with BAT SUVmean and SUVpeak (β = -0.273; R = 0.075; P = 0.003 and β = -0.255; R = 0.066; P = 0.005 respectively). In addition, the diet quality index for a Mediterranean diet and a pro-inflammatory dietary pattern (as determined via the dietary inflammatory index) were directly associated with BAT SUVmean and SUVpeak (SUVmean: β = 0.238; R = 0.053; P = 0.013 and β = 0.256; R = 0.052; P = 0.012 respectively; SUVpeak: β = 0.278; R = 0.073; P = 0.003 and β = 0.248; R = 0.049; P = 0.016 respectively). After controlling for multiplicity and possible confounders (sex, the evaluation wave and BMI), all the detected associations persisted.

CONCLUSION

Dietary factors are slightly associated with BAT volume and/or F-FDG uptake after a personalized cold exposure in young adults. Our results provide an overall picture of the potential relationships between dietary factors and BAT-related variables in humans.

摘要

目的

研究在年轻人进行个性化冷暴露后，常见饮食因素（饮食能量密度、营养素摄入、食物组消费和饮食模式）与棕色脂肪组织（BAT）体积/F-氟脱氧葡萄糖（F-FDG）摄取之间的关联。

方法

共有 122 名年轻成年人（n=82 名女性；22.0±2.1 岁；24.8±4.8kg/m）参与了这项横断面研究。通过食物频率问卷和三次非连续 24 小时回顾法测量饮食因素。饮食能量密度（包括食物和热量饮料）和宏量营养素摄入量随后使用 EvalFINUT®软件进行估算，食物组消费从食物频率问卷中估算，根据参考方法确定不同的饮食模式和质量指数。在 2 小时个性化冷暴露后，通过静态 F-FDG 正电子发射断层扫描和计算机断层扫描（PET-CT）评估 BAT 体积、BAT F-FDG 摄取和骨骼肌 F-FDG 摄取。

结果

饮食能量密度与 BAT 标准化摄取值（SUV）均值呈直接关联（β=0.215；R=0.044；P=0.022），乙醇消费与 BAT 体积呈直接关联（β=0.215；R=0.044；P=0.022）。预先确定的地中海饮食模式与 BAT SUV 均值和 SUV 峰值呈负相关（β=-0.273；R=0.075；P=0.003 和 β=-0.255；R=0.066；P=0.005）。此外，地中海饮食和促炎饮食模式的饮食质量指数（通过饮食炎症指数确定）与 BAT SUV 均值和 SUV 峰值呈直接相关（SUV 均值：β=0.238；R=0.053；P=0.013 和 β=0.256；R=0.052；P=0.012；SUV 峰值：β=0.278；R=0.073；P=0.003 和 β=0.248；R=0.049；P=0.016）。在控制了多重性和可能的混杂因素（性别、评估波和 BMI）后，所有检测到的关联仍然存在。