叶下珠中的双吲哚生物碱。
Bisindole alkaloids from Voacanga grandifolia leaves.
机构信息
Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku, Tokyo, 142-8501, Japan.
Faculty of Pharmacy, Airlangga University, Jalan Dharmawangsa Dalam, Surabaya, 60286, Indonesia.
出版信息
J Nat Med. 2021 Mar;75(2):408-414. doi: 10.1007/s11418-020-01475-w. Epub 2021 Jan 19.
Two new bisindole alkaloids, 12'-O-demethyl-vobtusine-5-lactam and isovobtusine-N-oxide (1 and 2), were isolated from the leaves of Voacanga grandifolia, together with two known bisindole alkaloids. Their structures were elucidated on the basis of 1D and 2D NMR data. 1 and 2 showed potent antimalarial activity against Plasmodium falciparum 3D7 and very low cytotoxic activity against a human cell line, HepG2 cells.
从 Voacanga grandifolia 的叶子中分离得到两个新的双吲哚生物碱，12'-O-去甲长春质碱-5-内酰胺和异长春质碱-N-氧化物（1 和 2），以及两个已知的双吲哚生物碱。基于 1D 和 2D NMR 数据阐明了它们的结构。1 和 2 对 Plasmodium falciparum 3D7 表现出很强的抗疟活性，对人肝癌细胞 HepG2 细胞的细胞毒性很低。
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