来自湄公河布西戈尼亚的细胞毒性埃博胺-阿斯皮多斯佩明型双吲哚生物碱。
Cytotoxic eburnamine-aspidospermine type bisindole alkaloids from Bousigonia mekongensis.
作者信息
Fu Yan-Hui, Li Shun-Lin, Li Shi-Fei, He Hong-Ping, Di Ying-Tong, Zhang Yu, Hao Xiao-Jiang
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China; Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, PR China.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China.
出版信息
Fitoterapia. 2014 Oct;98:45-52. doi: 10.1016/j.fitote.2014.07.008. Epub 2014 Jul 16.
Four new eburnamine-aspidospermine type bisindole alkaloids, namely, mekongenines C-F (1-4), along with 27 known indole alkaloids were isolated from the twigs and leaves of Bousigonia mekongensis. Their structures with the absolute configurations were elucidated by spectroscopic methods and ECD analyses. All new compounds were evaluated for their cytotoxicities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro. Alkaloids 1-4 exhibited inhibitory effects with IC50 values comparable to those of cisplatin.
从湄公盆架树的嫩枝和叶子中分离出4个新的埃博胺-阿马碱型双吲哚生物碱，即湄公盆架树碱C-F（1-4），以及27个已知的吲哚生物碱。通过光谱方法和ECD分析阐明了它们的结构及其绝对构型。对所有新化合物进行了体外抗5种人类癌细胞系（HL-60、SMMC-7721、A-549、MCF-7和SW480）的细胞毒性评价。生物碱1-4表现出抑制作用，其IC50值与顺铂相当。
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