沃氏非洲灵碱 A 和 B，来自. 的三聚体沃巴斯宁-阿朴卡林-阿朴卡林生物碱

Voatriafricanines A and B, Trimeric Vobasine-Aspidosperma-Aspidosperma Alkaloids from .

机构信息

Équipe "Chimie des Substances Naturelles" Université Paris-Saclay, CNRS, BioCIS, 5 Rue J.-B. Clément, 92290 Châtenay-Malabry, France.

Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon.

出版信息

J Nat Prod. 2021 Oct 22;84(10):2755-2761. doi: 10.1021/acs.jnatprod.1c00812. Epub 2021 Sep 26.

DOI:10.1021/acs.jnatprod.1c00812

PMID:34569237

Abstract

Voatriafricanines A and B ( and ), the first examples of vobasine-aspidosperma-aspidosperma monoterpene trisindole alkaloids, were isolated from the stem barks of , guided by a molecular networking strategy. Their structures, including absolute configurations, were elucidated by spectroscopic methods and ECD calculations. Compounds and possess intramolecular hydrogen bonding, sufficiently robust to transfer homonuclear and heteronuclear magnetizations. Compound exhibited potent antimycobacterial activity with no discernible cytotoxic activity.

摘要

Voatriafricanines A 和 B（和），是第一个 vobasine-aspidosperma-aspidosperma 单萜三吲哚生物碱的例子，是从的茎皮中分离出来的，这是一种基于分子网络策略的方法。它们的结构，包括绝对构型，是通过光谱方法和 ECD 计算来阐明的。化合物和具有分子内氢键，足够稳定，可以转移同核和异核磁化。化合物表现出很强的抗分枝杆菌活性，而没有明显的细胞毒性活性。