Laboratório Nacional de Nanotecnologia (LNNano), Centro Nacional de Pesquisa em Energia e Materiais (CNPEM), Campinas, SP, CEP 13083 970, Brasil.
Laboratório Nacional de Luz Síncrotron (LNLS), Centro Nacional de Pesquisa em Energia e Materiais (CNPEM), Campinas, SP, CEP 13083 970, Brasil.
Nanomedicine (Lond). 2021 Jan;16(2):85-96. doi: 10.2217/nnm-2020-0257. Epub 2021 Jan 19.
This work is focused on obtaining degradable mesoporous silica nanoparticles (DMSNs) which are able to maintain their colloidal stability in complex biological media. DMSNs were synthesized using different ratios of disulfide organosilane (degradable structural moiety) and further functionalized with sulfobetaine silane (SBS) to enhance colloidal stability and improve biological compatibility. There was a clear trade-off between nanoparticle degradability and colloidal stability, since full optimization of the degradation process generated unstable particles, while enhancing colloidal stability resulted in poor DMSNs degradation. It was also shown that acidic pH improved particle degradation which is commonly triggered by reduction stimulus. A chemical composition window was found where DMSNs presented satisfactory colloidal stability in biologically relevant medium, meaningful degradation profiles and high biocompatibility.
这项工作专注于获得可降解介孔硅纳米粒子（DMSNs），使其能够在复杂的生物介质中保持胶体稳定性。使用不同比例的二硫代有机硅烷（可降解结构部分）合成了 DMSNs，并进一步用磺酸甜菜碱硅烷（SBS）进行功能化，以增强胶体稳定性并提高生物相容性。纳米颗粒的降解性和胶体稳定性之间存在明显的权衡，因为完全优化降解过程会生成不稳定的颗粒，而增强胶体稳定性则会导致 DMSNs 降解不良。还表明，酸性 pH 会促进颗粒降解，这通常是由还原刺激引发的。研究发现了一个化学组成窗口，在该窗口中，DMSNs 在具有生物学意义的介质中表现出令人满意的胶体稳定性、有意义的降解谱和高生物相容性。
